Genetic variation in humans is sometimes described as being discontinuous among
continents or among groups of individuals, and by some this has been interpreted as genetic …

Microarray gene expression data provide a wealth of information for elucidating the mode
and tempo of molecular evolution. In the present study, we analyze the spatial expression …

Fay and Wu (1999) bring up a valuable point, that the time over which the pattern of
polymorphism responds to a change in population size will be greater for larger populations …

Positional cloning studies to identify disease genes are being carried out for many human
genetic diseases. Such studies often include a genome-scan linkage analysis to identify the …

Linkage disequilibrium (LD) and confounding are two widely discussed concepts in
Genetics and in Epidemiology, yet their relationship has received only intuitive or no …

A principal obstacle to completing maps and analyses of the human genome involves the
genome's" inaccessible" regions: sequences (often euchromatic and containing genes) that …

The International Haplotype Map (“HapMap”) Project is motivated, in part, by the belief that
the organization of the human genome, the mechanics of recombination, and the population …

Genetic variation among individual humans occurs on many different scales, ranging from
gross alterations in the human karyotype to single nucleotide changes. Here we explore …

Linkage disequilibrium—the nonrandom association of alleles at different loci—is a sensitive
indicator of the population genetic forces that structure a genome. Because of the explosive …

Genomewide association studies are set to become the tool of the future for detection of
small-effect genes in complex diseases. It will therefore be necessary to calculate sufficient …