Objective B-cell-activating factor (BAFF) and a proliferation-inducing ligand (APRIL)
signaling pathways regulate B-cell survival through interactions with their receptors BAFF-R …

B-cell activating factor belonging to tumour necrosis factor family (BAFF) is essential for B-
cell survival and function through interaction with its receptors BAFF receptor 3 (BR3), B-cell …

Background Systemic lupus erythematosus (SLE) is the prototype of systemic autoimmune
disease, characterized by loss of immune tolerance against self-antigens where …

Objective Elevated levels of BAFF and APRIL are characteristic of patients with systemic
lupus erythematosus (SLE). The reasons for enhanced cytokine production are not well …

B lymphocyte stimulator (BLyS) and APRoliferation inducing ligand (APRIL) are members of
the TNF superfamily that regulate B-cell survival and autoreactivity. To further understand …

Background B-cell activating factor of the TNF family (BAFF) promotes the maturation and
survival of B cells. Because BAFF levels are elevated in systemic lupus erythematosus (SLE) …

Introduction: The B-cell activating factor (BAFF) axis comprises two ligands (BAFF and
APRIL) and three receptors (BCMA, TACI, BR3). BAFF is a vital B-cell survival factor and …

Objectives Quantitating gene expression is a potential method of developing biomarkers in
systemic lupus erythematosus (SLE). Because of the known pathological role of B cell …

The tumour necrosis factor (TNF) family members B cell activating factor (BAFF) and APRIL
(a proliferation-inducing ligand) are crucial survival factors for peripheral B cells. An excess …

BAFF (B-cell–activating factor) is a critical survival factor for transitional and mature B cells
and is a promising therapeutic target for systemic lupus erythematosus (SLE). In 2010–2011 …