Abstract The Methanococcus jannaschii tRNATyr/TyrRS pair has been engineered to
incorporate unnatural amino acids into proteins in E. coli. To reveal the structural basis for …

PROTEIN tyrosine phosphatases (PTPases) and kinases coregulate the critical levels of
phosphorylation necessary for intracellular signalling, cell growth and differentiation1, 2 …

High accuracy mass spectrometry has proven to be a powerful technology for the large scale
identification of serine/threonine/tyrosine phosphorylation in the living cell. However, despite …

Protein tyrosine phosphatases (PTPs) possess a conserved mobile catalytic loop, the WPD-
loop, which brings an aspartic acid into the active site where it acts as an acid/base catalyst …

In the developing embryo, cell growth, differentiation, and migration are strictly regulated by
complex signaling pathways. One of the most important cell signaling mechanisms is protein …

Reversible tyrosine phosphorylation plays a crucial role in signal transduction, regulating
many biological functions including proliferation, differentiation, and motility. The …

Tyrosine phosphorylation and protein recognition, mediated by phosphotyrosine containing
peptides, play an important role in determining the specific response of a cell, when …

Although members of the protein tyrosine phosphatase (PTP) family are known to play
critical roles in various cellular processes through the regulation of protein tyrosine …

Small molecules that can be used to specifically control the activity of cellular gene products
are key tools in chemical biology. Here, we present a scanning− insertional− mutagenesis …

Protein phosphorylation is a crucial regulator of protein and cellular function, yet, despite
identifying an enormous number of phosphorylation sites, the role of most is still unclear …