Background Nucleotide leukin-rich polypeptide 3 (NLRP3) inflammasome is documented as
a potent target for treating metabolic diseases and inflammatory disorders. Our recent work …

Diabetic nephropathy (DN) is the leading cause of end-stage renal disease. Activation of the
nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing …

Efficient therapies for diabetic kidney disease (DKD), now the leading cause of kidney
failure, are lacking. One hallmark of DKD is sterile inflammation (inflammation in absence of …

While inflammation is considered a central component in the development in diabetic
nephropathy, the mechanism remains unclear. The NLRP3 inflammasome acts as both a …

Diabetic nephropathy (DN) is a serious complication of diabetes mellitus, and persistent
inflammation in circulatory and renal tissues is an important pathophysiological basis for DN …

Activation of nucleotide-binding oligomerization domain-like receptor pyrin domain
containing 3 (NLRP3) inflammasome has been reported in diabetic complications including …

Background: Diabetic nephropathy (DN) is one of the most serious complications of diabetes
mellitus and the main cause of the end-stage renal disease (ESRD). Activation of the NLRP3 …

Highlights•NLRP3 inflammasome activity plays an important role in inflammatory
responses.•NLRP3 inflammasome is also implicated in diabetic nephropathy (DN) …

Background Diabetic nephropathy (DN) is a lethal diabetic microvascular complication
characterized by chronic low-grade inflammation. The NOD-like receptor pyrin domain …

Diabetic nephropathy (DN) is one of the most common complications of diabetes and the
main cause of end-stage renal disease (ESRD). The inflammatory response plays a key role …