Mammalian target of rapamycin: its role in early neural development and in adult and aged brain function

C Garza-Lombó, ME Gonsebatt - Frontiers in cellular neuroscience, 2016 - frontiersin.org
The kinase mammalian target of rapamycin (mTOR) integrates signals triggered by energy,
stress, oxygen levels, and growth factors. It regulates ribosome biogenesis, mRNA …

Role of mTOR in physiology and pathology of the nervous system

L Swiech, M Perycz, A Malik, J Jaworski - Biochimica et Biophysica Acta …, 2008 - Elsevier
Mammalian target of rapamycin (mTOR) is a serine–threonine protein kinase that regulates
several intracellular processes in response to extracellular signals, nutrient availability …

mTOR signaling and its roles in normal and abnormal brain development

N Takei, H Nawa - Frontiers in molecular neuroscience, 2014 - frontiersin.org
Target of rapamycin (TOR) was first identified in yeast as a target molecule of rapamycin, an
anti-fugal and immunosuppressant macrolide compound. In mammals, its orthologue is …

Mammalian Target of Rapamycin: Hitting the Bull′ s‐Eye for Neurological Disorders

ZZ Chong, YC Shang, L Zhang… - … medicine and cellular …, 2010 - Wiley Online Library
The mammalian target of rapamycin (mTOR) and its associated cell signaling pathways
have garnered significant attention for their roles in cell biology and oncology. Interestingly …

Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin

ZZ Chong, YC Shang, S Wang, K Maiese - Progress in neurobiology, 2012 - Elsevier
Neurodegenerative disorders affect a significant portion of the world's population leading to
either disability or death for almost 30 million individuals worldwide. One novel therapeutic …

[HTML][HTML] Molecular neurobiology of mTOR

K Switon, K Kotulska, A Janusz-Kaminska… - Neuroscience, 2017 - Elsevier
Mammalian/mechanistic target of rapamycin (mTOR) is a serine-threonine kinase that
controls several important aspects of mammalian cell function. mTOR activity is modulated …

[HTML][HTML] Mammalian target of rapamycin (mTOR) pathways in neurological diseases

M Wong - Biomedical journal, 2013 - ncbi.nlm.nih.gov
The mammalian target of rapamycin (mTOR) pathway is an essential cellular signaling
pathway involved in a number of important physiological functions, including cell growth …

Driving neural regeneration through the mammalian target of rapamycin

K Maiese - Neural regeneration research, 2014 - journals.lww.com
Neurodegenerative disorders affect more than 30 million individuals throughout the world
and lead to significant disability as well as death. These statistics will increase almost …

mTOR mysteries: nuances and questions about the mechanistic target of rapamycin in neurodegeneration

NG Norwitz, H Querfurth - Frontiers in Neuroscience, 2020 - frontiersin.org
The mechanistic target of rapamycin protein complex, mTORC1, has received attention in
recent years for its role in aging and neurodegenerative diseases, such as Alzheimer's …

mTOR in brain physiology and pathologies

J Bockaert, P Marin - Physiological reviews, 2015 - journals.physiology.org
TOR (target of rapamycin) and its mammalian ortholog mTOR have been discovered in an
effort to understand the mechanisms of action of the immunosuppressant drug rapamycin …