Organoid systems to study the human female reproductive tract and pregnancy
Both the proper functioning of the female reproductive tract (FRT) and normal placental
development are essential for women's health, wellbeing, and pregnancy outcome. The …
development are essential for women's health, wellbeing, and pregnancy outcome. The …
Organoids of the female reproductive tract
C Chumduri, MY Turco - Journal of molecular medicine, 2021 - Springer
Healthy functioning of the female reproductive tract (FRT) depends on balanced and
dynamic regulation by hormones during the menstrual cycle, pregnancy and childbirth. The …
dynamic regulation by hormones during the menstrual cycle, pregnancy and childbirth. The …
Organoid technology in female reproductive biomedicine
H Heidari-Khoei, F Esfandiari, MA Hajari… - Reproductive Biology …, 2020 - Springer
Recent developments in organoid technology are revolutionizing our knowledge about the
biology, physiology, and function of various organs. Female reproductive biology and …
biology, physiology, and function of various organs. Female reproductive biology and …
Organoids to model the endometrium: implantation and beyond
TM Rawlings, K Makwana, M Tryfonos… - Reproduction and …, 2021 - raf.bioscientifica.com
Despite advances in assisted reproductive techniques in the 4 decades since the first
human birth after in vitro fertilisation, 1–2% of couples experience recurrent implantation …
human birth after in vitro fertilisation, 1–2% of couples experience recurrent implantation …
Investigation of infertility using endometrial organoids
K Nikolakopoulou, MY Turco - Reproduction, 2021 - rep.bioscientifica.com
Infertility is a common problem in modern societies with significant socio-psychological
implications for women. Therapeutic interventions are often needed which, depending on …
implications for women. Therapeutic interventions are often needed which, depending on …
Human-derived model systems in gynecological cancer research
K Lõhmussaar, M Boretto, H Clevers - Trends in cancer, 2020 - cell.com
The human female reproductive tract (FRT) is a complex system that combines series of
organs, including ovaries, fallopian tubes, uterus, cervix, vagina, and vulva; each of which …
organs, including ovaries, fallopian tubes, uterus, cervix, vagina, and vulva; each of which …
Development of organoids from mouse and human endometrium showing endometrial epithelium physiology and long-term expandability
M Boretto, B Cox, M Noben, N Hendriks… - …, 2017 - journals.biologists.com
The endometrium, which is of crucial importance for reproduction, undergoes dynamic cyclic
tissue remodeling. Knowledge of its molecular and cellular regulation is poor, primarily …
tissue remodeling. Knowledge of its molecular and cellular regulation is poor, primarily …
Long-term organoid culture reveals enrichment of organoid-forming epithelial cells in the fimbrial portion of mouse fallopian tube
Y Xie, ES Park, D Xiang, Z Li - Stem cell research, 2018 - Elsevier
A recent paradigm shift in ovarian cancer research is the finding that many ovarian cancers
may originate from fallopian tube epithelial (FTE) cells. As tissue stem and progenitor cells …
may originate from fallopian tube epithelial (FTE) cells. As tissue stem and progenitor cells …
Strategies for modelling endometrial diseases
AR Murphy, H Campo, JJ Kim - Nature Reviews Endocrinology, 2022 - nature.com
Each month during a woman's reproductive years, the endometrium undergoes vast
changes to prepare for a potential pregnancy. Diseases of the endometrium arise for …
changes to prepare for a potential pregnancy. Diseases of the endometrium arise for …
Modeling human trophoblast, the placental epithelium at the maternal fetal interface
M Horii, O Touma, T Bui, MM Parast - Reproduction, 2020 - rep.bioscientifica.com
Appropriate human trophoblast lineage specification and differentiation is crucial for the
establishment of normal placentation and maintenance of pregnancy. However, due to the …
establishment of normal placentation and maintenance of pregnancy. However, due to the …