Relapse to drug seeking following prolonged abstinence: the role of environmental stimuli

RA Fuchs, HC Lasseter, DR Ramirez, X Xie - Drug Discovery Today …, 2008 - Elsevier
Successful treatment of drug addiction must involve relapse prevention informed by our
understanding of the neurobiological bases of drug relapse. In humans, exposure to drug …

[HTML][HTML] The winding road to relapse: forging a new understanding of cue-induced reinstatement models and their associated neural mechanisms

MD Namba, SE Tomek, MF Olive… - Frontiers in behavioral …, 2018 - frontiersin.org
In drug addiction, cues previously associated with drug use can produce craving and
frequently trigger the resumption of drug taking in individuals vulnerable to relapse …

[HTML][HTML] Anti-relapse neurons in the infralimbic cortex of rats drive relapse-suppression by drug omission cues

A Laque, G L. De Ness, GE Wagner… - Nature …, 2019 - nature.com
Drug addiction is a chronic relapsing disorder of compulsive drug use. Studies of the
neurobehavioral factors that promote drug relapse have yet to produce an effective …

Animal models of drug relapse and craving: from drug priming-induced reinstatement to incubation of craving after voluntary abstinence

M Venniro, D Caprioli, Y Shaham - Progress in brain research, 2016 - Elsevier
High rates of relapse to drug use during abstinence is a defining feature of drug addiction. In
abstinent drug users, drug relapse is often precipitated by acute exposure to the self …

Recent developments in animal models of drug relapse

NJ Marchant, X Li, Y Shaham - Current opinion in neurobiology, 2013 - Elsevier
Drug craving and relapse to drug use during abstinence are defining features of addiction.
Evidence indicates that drug craving and relapse in humans are often provoked by acute …

Targeting extinction and reconsolidation mechanisms to combat the impact of drug cues on addiction

JR Taylor, P Olausson, JJ Quinn, MM Torregrossa - Neuropharmacology, 2009 - Elsevier
Drug addiction is a progressive and compulsive disorder, where recurrent craving and
relapse to drug-seeking occur even after long periods of abstinence. A major contributing …

Forced abstinence model of relapse to study pharmacological treatments of substance use disorder

CM Reichel, RA Bevins - Current drug abuse reviews, 2009 - ingentaconnect.com
Understanding and preventing relapse to drug use is one of the most difficult challenges
faced by clinicians and practitioners in the struggle to help people remain abstinent. In this …

Reinstatement—toward a model of relapse

Y Shaham, KA Miczek - Psychopharmacology, 2003 - Springer
High rate of relapse to drug use after periods of abstinence is the most difficult clinical
problem in the treatment of human drug addiction (Hunt et al. 1971; O'Brien 1997) …

Animal models of drug relapse and craving after voluntary abstinence: a review

I Fredriksson, M Venniro, DJ Reiner, JJ Chow… - Pharmacological …, 2021 - ASPET
Relapse to drug use during abstinence is a defining feature of addiction. During the last
several decades, this clinical scenario has been studied at the preclinical level using classic …

Advances in animal models of relapse for addiction research

F Weiss - Advances in the Neuroscience of Addiction, 2010 - books.google.com
Drug addiction is a chronically relapsing disorder characterized by compulsive drugseeking
and use (Leshner 1997; McLellan et al. 2000; O'Brien et al. 1998; O'Brien and McLellan …