Pharmacomicrobiomics: exploiting the drug-microbiota interactions in antihypertensive treatment

HQ Chen, JY Gong, K Xing, MZ Liu, H Ren… - Frontiers in …, 2022 - frontiersin.org
Hypertension is a leading risk factor for cardiovascular diseases and can reduce life
expectancy. Owing to the widespread use of antihypertensive drugs, patients with …

The metabolic role and therapeutic potential of the microbiome

LE Olofsson, F Bäckhed - Endocrine reviews, 2022 - academic.oup.com
We are host to an assembly of microorganisms that vary in structure and function along the
length of the gut and from the lumen to the mucosa. This ecosystem is collectively known as …

Dysbiotic gut microbes may contribute to hypertension by limiting vitamin D production

K Zuo, J Li, Q Xu, C Hu, Y Gao, M Chen, R Hu… - Clinical …, 2019 - Wiley Online Library
Background Accumulating studies have suggested that gut microbiota (GM) dysbiosis and
vitamin D3 deficiency each play an important role during the progression of hypertension …

Blood microbiota dysbiosis is associated with the onset of cardiovascular events in a large general population: the DESIR study

J Amar, C Lange, G Payros, C Garret, C Chabo… - PloS one, 2013 - journals.plos.org
Aim We recently described a human blood microbiome and a connection between this
microbiome and the onset of diabetes. The aim of the current study was to assess the …

Gut microbiome and its role in cardiovascular diseases

S Ahmadmehrabi, WHW Tang - Current opinion in cardiology, 2017 - journals.lww.com
Although our understanding of gut microbiota–host interactions has increased recently;
many questions remain about the mechanistic links between the gut microbiome and CVD …

Gut microbiota and cardiovascular disease

M Witkowski, TL Weeks, SL Hazen - Circulation research, 2020 - Am Heart Assoc
Fecal microbial community changes are associated with numerous disease states, including
cardiovascular disease (CVD). However, such data are merely associative. A causal …

Assessing the human gut microbiota in metabolic diseases

F Karlsson, V Tremaroli, J Nielsen, F Bäckhed - Diabetes, 2013 - Am Diabetes Assoc
Recent findings have demonstrated that the gut microbiome complements our human
genome with at least 100-fold more genes. In contrast to our Homo sapiens–derived genes …

Evaluating causality of gut microbiota in obesity and diabetes in humans

AS Meijnikman, VE Gerdes, M Nieuwdorp… - Endocrine …, 2018 - academic.oup.com
The pathophysiology of obesity and obesity-related diseases such as type 2 diabetes
mellitus (T2DM) is complex and driven by many factors. One of the most recently identified …

Metagenomic and metabolomic analyses unveil dysbiosis of gut microbiota in chronic heart failure patients

X Cui, L Ye, J Li, L Jin, W Wang, S Li, M Bao, S Wu… - Scientific reports, 2018 - nature.com
Previous studies suggested a possible gut microbiota dysbiosis in chronic heart failure
(CHF). However, direct evidence was lacking. In this study, we investigated the composition …

The emerging role of the gut microbiome in cardiovascular disease: Current knowledge and perspectives

PD Papadopoulos, C Tsigalou, PN Valsamaki… - Biomedicines, 2022 - mdpi.com
The collection of normally non-pathogenic microorganisms that mainly inhabit our gut lumen
shapes our health in many ways. Structural and functional perturbations in the gut microbial …