Oxygen free radicals in excessively high amounts are all very reactive chemically and can
impose a detrimental influence on living organisms by provoking “oxidative stress” that can …

Reactive oxygen species (ROS) are generated as by-products of normal cellular metabolic
activities. Superoxide dismutase, glutathione peroxidase, and catalase are the enzymes …

Inflammatory bowel disease (IBD) comprises primarily the chronic relapsing inflammatory
disorders, Crohn's disease and ulcerative colitis, with the former affecting any part of the …

Accumulating evidence shows that oxidative stress plays an essential role in the
pathogenesis and progression of many diseases. The imbalance between the production of …

Significance: The role of reactive oxygen/nitrogen species as “friend” or “foe” messengers in
the whole body is well characterized. Depending on the concentration in the tissue …

Virtually all inflammatory mediators investigated to date seem to be dysregulated in the
inflamed intestinal mucosa of patients with inflammatory bowel disease. However, which of …

Redox signaling regulates physiological self-renewal, proliferation, migration and
differentiation in gastrointestinal epithelium by modulating Wnt/β-catenin and Notch …

Oxidative stress in this section will refer to the availability of free radicals to react with target
tissues because of inadequate antioxidant capacity or bioavailability. One major target for …

Oxidative stress is thought to play a key role in the development of intestinal damage in
inflammatory bowel disease (IBD), because of its primary involvement in intestinal cells' …

Background: Chronic inflammation is linked to an increased risk of cancer. The molecular
mechanisms underlying this correlation have been long investigated and it is well known …