Inhaled β 2-adrenoceptor agonists (β 2-agonists) are the most commonly used asthma
medications in many Western countries. Minor adverse effects such as palpitations, tremor …

Links between frequent use of inhaled β2-agonists and morbidity and mortality from asthma
appear probable. Two mortality epidemics followed the marketing of potent inhaled …

Background. Morbidity and mortality from asthma appear to be increasing, and it has been
suggested that medications used to treat asthma are contributing to this trend. We …

Several studies suggested an association between the regular use of β 2-agonists and
asthma deaths. Whether this association represents adverse effects of β-agonist use or is …

The decision by the Food and Drug Administration to issue a “black box” warning for long-
acting β-agonists has been followed by a series of pharmacoepidemiological studies …

Regular treatment with both long-and short-acting β 2-agonists results in tolerance to their
bronchoprotective effects, although the relevance of this phenomenon in terms of long term …

Abstract β-Agonists have clearly demonstrated benefits for the treatment of both acute and
chronic asthma. Therefore, it is perhaps surprising that many of the articles in this issue have …

Inhaled β 2-agonists, when used regulary, cause subtle but significant worsening of asthma
control. Overuse of inhaled β 2-agonists is associated with increased risk of death from …

The association between the use of inhaled beta-agonists and the risk of death and near-
death from asthma has previously been reported. It was based on a nested case-control …

In this article, studies that have examined the effects on morbidity and mortality of β-agonist
drugs are reviewed. With regard to morbidity, there is considerable evidence that the regular …