Abstract Background Carboxylesterases (CEs) belong to the serine hydrolase family, and
are in charge of hydrolyzing chemicals with carboxylic acid ester and amide functional …

In our search for natural human carboxylesterase 2 (hCE 2) inhibitors from natural products,
we investigated inhibitory effects and mechanisms of flavonoids (1–16) against hCE 2. The …

Human carboxylesterase 1 (hCE1), one of the most important serine hydrolases distributed
in liver and adipocytes, plays key roles in endobiotic homeostasis and xenobiotic …

In this study, forty-nine kinds of traditional Chinese medicines (TCMs) were evaluated for
their inhibitory activities against human carboxylesterase 2 (HCE 2) using a human liver …

Abstract Human Carboxylesterase 2A (hCES2A), one of the most important serine
hydrolases, plays crucial roles in the hydrolysis and the metabolic activation of a wide range …

Abstract Human carboxylesterase 1 (hCE1) is a key enzyme responsible for the hydrolysis of
a wide range of endogenous and xenobiotic esters, but the highly selective inhibitors …

Abstract Laportea bulbifera (Sieb. et. Zucc.) Wedd has long been utilized in Traditional
Chinese Medicines (TCM) for the treatment of rheumatoid arthritis. However, the study of …

As a part of our searching for natural human carboxylesterase 2 (human CES 2) inhibitors
from traditional Chinese medicine, we found that the extract of Alisma orientale significantly …

Human carboxylesterases (hCEs) are key enzymes from the serine hydrolase superfamily.
Among all identified hCEs, human carboxylesterase 2 (hCE2) plays crucial roles in the …

Shikonin, a natural naphthoquinone compound derived from the herb Lithospermum
erythrorhizon, is widely used for its various pharmacological activities. However, its potential …