Role of aquaporin water channels in kidney and lung

AS Verkman - The American journal of the medical sciences, 1998 - Elsevier
Several aquaporin-type water channels are expressed in mammalian kidney and lung:
AQP1 in lung microvessels and kidney proximal tubule, thin descending limb of Henle, and …

Role of water channels in fluid transport studied by phenotype analysis of aquaporin knockout mice

AS Verkman, B Yang, Y Song… - Experimental …, 2000 - Wiley Online Library
Aquaporin‐type water channels are expressed widely in mammalian tissues, particularly in
the kidney, lung, eye and gastrointestinal tract. To define the role of aquaporins in organ …

Physiological importance of aquaporin water channels

AS Verkman - Annals of medicine, 2002 - Taylor & Francis
Aquaporins (AQP) are a family of at least ten homologous water transporting proteins in
mammals that are expressed in many epithelial, endothelial and other tissues. Abnormalities …

Dissecting the roles of aquaporins in renal pathophysiology using transgenic mice

AS Verkman - Seminars in nephrology, 2008 - Elsevier
Transgenic mice lacking renal aquaporins (AQPs), or containing mutated AQPs, have been
useful in confirming anticipated AQP functions in renal physiology and in discovering new …

Lessons on renal physiology from transgenic mice lacking aquaporin water channels

AS Verkman - Journal of the American Society of Nephrology, 1999 - journals.lww.com
Several aquaporin-type water channels are expressed in kidney: AQP1 in the proximal
tubule, thin descending limb of Henle, and vasa recta; AQP2, AQP3, and AQP4 in the …

Renal concentrating and diluting function in deficiency of specific aquaporin genes

AS Verkman - Experimental nephrology, 2002 - karger.com
Aquaporins (AQP) are water-transporting proteins expressed in many fluid-transporting
epithelia and endothelia. In kidney, AQP1 is expressed in plasma membranes of proximal …

Aquaporin-1 water channel protein in lung: ontogeny, steroid-induced expression, and distribution in rat.

LS King, S Nielsen, P Agre - The Journal of clinical …, 1996 - Am Soc Clin Investig
At birth water is rapidly reabsorbed from the distal lung in preparation for alveolar gas
exchange. To investigate a potential role for the AQP1 water channel in development, lung …

Roles of aquaporins in kidney revealed by transgenic mice

AS Verkman - Seminars in nephrology, 2006 - Elsevier
Transgenic mouse models of aquaporin (AQP) deletion and mutation have been instructive
in elucidating the role of AQPs in renal physiology. Mice lacking AQP1 are unable to …

Aquaporin water channels in mammals

K Ishibashi, S Hara, S Kondo - Clinical and experimental nephrology, 2009 - Springer
Abstract Water channels, aquaporins (AQPs), are a family of small integral plasma
membrane proteins that primarily transport water across the plasma membrane. There are …

Nephrogenic diabetes insipidus in mice lacking aquaporin-3 water channels

T Ma, Y Song, B Yang, A Gillespie… - Proceedings of the …, 2000 - National Acad Sciences
Aquaporin-3 (AQP3) is a water channel expressed at the basolateral plasma membrane of
kidney collecting-duct epithelial cells. The mouse AQP3 cDNA was isolated and encodes a …