Mono-and diaminated 2′-amino-LNA monomers were synthesized and introduced into
oligonucleotides. Each modification imparts significant stabilization of nucleic acid duplexes …

9-Mer DNA sequences containing 2′-N-methyl-2′-N-(pyren-1-ylmethyl)-2′-amino-DNA
monomers display significantly increased affinity towards DNA complements whereas the …

Synthesis of three different amide-linked LNA-type dinucleotides and their incorporation into
9-mer and 17-mer oligodeoxynucleotides is described; compared to the reference DNA …

4′-C-[N, N-Di (4-pentyn-1-yl) aminomethyl] thymidine and 4′-C-[N-methyl-N-(4-pentyn-1-
yl) aminomethyl] thymidine 3′-(2-cyanoethyl-N, N-diisopropyl) phosphoramidites (1, 2) …

The development of conformationally restricted nucleotide building blocks continues to
attract considerable interest because of their successful use within antisense, antigene, and …

Thymin-1-yl-acetic acid and adenin-9-yl-acetic acid have been coupled to the N2′-atom of
a 2′-amino-LNA thymine nucleoside, and these “double-headed” LNA monomers have …

Conspectus Incorporation of chemically modified nucleotide scaffolds into nucleic acids to
form assemblies rich in function is an innovative area with great promise for nanotechnology …

The potential of chemically modified oligonucleotide (ON) analogues as therapeutic agents
or diagnostic molecules has stimulated great interest in nucleic acid mimics during recent …

A convenient method for the preparation of oligonucleotides containing internally-attached
galactose and triantennary galactose units has been developed based on click chemistry …

3′-5′-Deoxyribose-sugar-phoshate backbone in DNA is completely replaced by 2′-
deoxyribonucleoside-based β-amino acids interlinked by glycine to create uncharged …