Complement proteins are ancient components of innate immunity that have emerged as
crucial regulators of neural networks. We discuss these roles in the context of the CNS …

The functions of the complement system to both innate and adaptive immunity through
opsonization, cell lysis, and inflammatory activities are well known. In contrast, the role of …

The complement cascade is an important arm of the immune system that plays a key role in
protecting the central nervous system (CNS) from infection. Recently, it has also become …

The last 15 years have seen an explosion of new findings on the role of complement, a
major arm of the immune system, in the central nervous system (CNS) compartment …

Complement is an important component of the innate immune response with the capacity to
recognize and clear infectious challenges that invade the CNS through a damaged blood …

The complement system is an ancient collection of proteolytic cascades with well-described
roles in regulation of innate and adaptive immunity. With the convergence of a revolution in …

Growing evidence points to a previously elusive role of complement-modulated pathways in
CNS development, neurogenesis and synaptic plasticity. Distinct complement effectors …

The complement system was long considered as only a powerful effector arm of the immune
system that, while critically protective, could lead to inflammation and cell death if …

While the mechanisms underlying the functions of the complement system in the central
nervous system (CNS) and systemically, namely opsonization, chemotaxis, membrane lysis …

The complement system, a major component of the innate immune system, is becoming
increasingly recognised as a key participant in physiology and disease. The awareness that …