Ferulic Acid Ameliorates MPP+/MPTP-Induced Oxidative Stress via ERK1/2-Dependent Nrf2 Activation: Translational Implications for Parkinson Disease Treatment

X Li, J Zhang, H Rong, X Zhang, M Dong - Molecular neurobiology, 2020 - Springer
Parkinson's disease (PD) is a neurodegenerative disorder closely associated with oxidative
stress. The biochemical and cellular alterations that occur after cell and mouse treatment …

Paeoniflorin and Plycyrrhetinic Acid Synergistically Alleviate MPP+/MPTP-Induced Oxidative Stress through Nrf2-Dependent Glutathione Biosynthesis Mechanisms

H Dong, J Zhang, H Rong, X Zhang… - ACS Chemical …, 2021 - ACS Publications
Recently, combination therapy has proven to be an effective strategy for treating polygenic/
multifactorial/complex disorder such as Parkinson's disease (PD). Here, we hypothesized …

Distinct Nrf2 signaling mechanisms of fumaric acid esters and their role in neuroprotection against 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced …

M Ahuja, NA Kaidery, L Yang… - Journal of …, 2016 - Soc Neuroscience
A promising approach to neurotherapeutics involves activating the nuclear-factor-E2-related
factor 2 (Nrf2)/antioxidant response element signaling, which regulates expression of …

Bruceine D elevates Nrf2 activation to restrain Parkinson's disease in mice through suppressing oxidative stress and inflammatory response

Y Yang, F Kong, Q Ding, Y Cai, Y Hao… - … and Biophysical Research …, 2020 - Elsevier
Parkinson's disease (PD) is neurodegenerative disease, featured by a loss of dopaminergic
neurons in the substantia nigra pars compacta (SNpc), characteristic motor symptoms and …

Puerarin suppresses MPP+/MPTP-induced oxidative stress through an Nrf2-dependent mechanism

X Li, J Zhang, X Zhang, M Dong - Food and Chemical Toxicology, 2020 - Elsevier
In this study, we hypothesized that anti-parkinsonian effect of puerarin is attributable to its
antioxidant properties via Nrf2-dependent glutathione (GSH) biosynthesis mechanism …

Targeting Nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP mouse model of Parkinson's …

NA Kaidery, R Banerjee, L Yang… - Antioxidants & redox …, 2013 - liebertpub.com
Although the etiology of Parkinson's disease (PD) remains unclear, ample empirical
evidence suggests that oxidative stress is a major player in the development of PD and in 1 …

Ferulic acid pretreatment mitigates MPTP-induced motor impairment and histopathological alterations in C57BL/6 mice

S Nagarajan, DR Chellappan… - Pharmaceutical …, 2015 - Taylor & Francis
Context: Ferulic acid (FA) is a potent ubiquitous plant antioxidant found in cereals such as
brown rice, whole wheat, and oats. Phytochemical-based antioxidants are shown to be …

Nrf2 activation by tauroursodeoxycholic acid in experimental models of Parkinson's disease

S Moreira, I Fonseca, MJ Nunes, A Rosa, L Lemos… - Experimental …, 2017 - Elsevier
Parkinson's disease (PD) is a progressive neurological disorder, mainly characterized by the
loss of dopaminergic neurons in the substantia nigra pars compacta. Although the cause of …

Dimethyl fumarate attenuates 6-OHDA-induced neurotoxicity in SH-SY5Y cells and in animal model of Parkinson's disease by enhancing Nrf2 activity

X Jing, H Shi, C Zhang, M Ren, M Han, X Wei, X Zhang… - Neuroscience, 2015 - Elsevier
Oxidative stress is central to the pathology of several neurodegenerative diseases, including
Parkinson's disease (PD), and therapeutics designed to enhance antioxidant potential could …

Alpha lipoic acid ameliorates motor deficits by inhibiting ferroptosis in Parkinson's disease

Q Zheng, P Ma, P Yang, S Zhai, M He, X Zhang, Q Tu… - Neuroscience …, 2023 - Elsevier
Parkinson's disease (PD) is a neurodegenerative disease. Ferroptosis shares several
features with PD pathophysiology, and anti-ferroptosis molecules are neuroprotective in PD …