In the kidney, hypoxia contributes to tubulointerstitial fibrosis, but little is known about its
implications for glomerular damage and glomerulosclerosis. Chronic hypoxia was …

Accumulating evidence suggests that dysregulation of hypoxia-regulated transcriptional
mechanisms is involved in development of chronic kidney diseases (CKD). However, it …

Chemokines play pivotal roles in the recruitment of inflammatory cells into the kidney. The
chemokine receptors CXCR3 and CCR5 are expressed on activated T lymphocytes, and …

Renal fibrosis is the final stage of most progressive kidney diseases. Chronic kidney disease
(CKD) is associated with high comorbidity and mortality. Thus, preventing fibrosis and …

Renal fibrosis is the common pathological hallmark of progressive chronic kidney disease
(CKD) with diverse aetiologies. Recent researches have highlighted the critical role of …

Renal fibrosis is characterized by tubular cell atrophy and accumulation of extracellular
matrix. Fibroblast activation becomes evident in areas surrounding atrophic tubules, with …

Many clinical observations suggest common mediators in the progression of kidney disease
leading to eventual kidney failure. Among them, accumulating evidence emphasizes the role …

Hypoxia-inducible factor (HIF) is a key transcriptional factor in the response to hypoxia.
Although the effect of HIF activation in chronic kidney disease (CKD) has been widely …

Hypertensive chronic kidney disease is one of the most prevalent medical conditions with
high morbidity and mortality in the United States and worldwide. However, early events …

Recent studies underscore that chronic hypoxia in the tubulointerstitium is a final common
pathway to progression to end-stage renal failure regardless of etiology. We used …