Hydroxytyrosol plays antiatherosclerotic effects through regulating lipid metabolism via inhibiting the p38 signal pathway

X Zhang, Y Qin, X Wan, H Liu, C Iv… - BioMed Research …, 2020 - Wiley Online Library
Purpose. Hydroxytyrosol (HT) processes multiaspect pharmacological properties such as
antithrombosis and antidiabetes. The aim of this study was to explore the antistherosclerotic …

Wide biological role of hydroxytyrosol: possible therapeutic and preventive properties in cardiovascular diseases

C D'Angelo, S Franceschelli, JL Quiles, L Speranza - Cells, 2020 - mdpi.com
The growing incidence of cardiovascular disease (CVD) has promoted investigations of
natural molecules that could prevent and treat CVD. Among these, hydroxytyrosol, a …

Molecular action of hydroxytyrosol in attenuation of intimal hyperplasia: a scoping review

U Vijakumaran, MD Yazid, RB Hj Idrus… - Frontiers in …, 2021 - frontiersin.org
Objective: Hydroxytyrosol (HT), a polyphenol of olive plant is well known for its antioxidant,
anti-inflammatory and anti-atherogenic properties. The aim of this systematic search is to …

Hydroxytyrosol Reduces Foam Cell Formation and Endothelial Inflammation Regulating the PPARγ/LXRα/ABCA1 Pathway

S Franceschelli, F De Cecco, M Pesce, P Ripari… - International journal of …, 2023 - mdpi.com
Cholesterol accumulation in macrophages leads to the formation of foam cells and
increases the risk of developing atherosclerosis. We have verified whether hydroxytyrosol …

Hydroxytyrosol and its main plasma circulating metabolites attenuate the initial steps of atherosclerosis through inhibition of the MAPK pathway

Ú Catalán, MCL de las Hazas, C Piñol, L Rubió… - Journal of Functional …, 2018 - Elsevier
The main aim of this work is to gain insight into the potential mechanisms of hydroxytyrosol
(HT) and its main plasmatic metabolites (HTmet) that improve the endothelial function …

3-Hydroxytyrosol promotes angiogenesis in vitro by stimulating endothelial cell migration

M Abate, S Pisanti, M Caputo, M Citro… - International Journal of …, 2020 - mdpi.com
Cardiovascular diseases, followed by strokes, represent the leading cause of mortality
worldwide. Despite its success in preventing cardiovascular diseases, the therapeutic …

Effects of hydroxytyrosol in endothelial functioning: a comprehensive review

U Vijakumaran, J Shanmugam, JW Heng, SS Azman… - Molecules, 2023 - mdpi.com
Pharmacologists have been emphasizing and applying plant and herbal-based treatments
in vascular diseases for decades now. Olives, for example, are a traditional symbol of the …

Hydroxytyrosol reduces intracellular reactive oxygen species levels in vascular endothelial cells by upregulating catalase expression through the AMPK–FOXO3a …

H Zrelli, M Matsuoka, S Kitazaki, M Zarrouk… - European Journal of …, 2011 - Elsevier
Reactive oxygen species are critically involved in the endothelial dysfunction that
contributes to atherosclerosis development. Hydroxytyrosol (HT), a main phenolic …

Hydroxytyrosol modulates adipocyte gene and miRNA expression under inflammatory condition

E Scoditti, S Carpi, M Massaro, M Pellegrino, B Polini… - Nutrients, 2019 - mdpi.com
Chronic inflammation of the adipose tissue (AT) is a major contributor to obesity-associated
cardiometabolic complications. The olive oil polyphenol hydroxytyrosol (HT) contributes to …

Hydroxytyrosol: Its role in the prevention of cardiovascular diseases

C Noguera-Navarro, S Montoro-García… - Heliyon, 2023 - cell.com
In recent years, non-pharmacology treatments and their effectiveness have gained
popularity due to their beneficial properties in the prevention of cardiovascular diseases …