Complement C3aR depletion reverses HIF-1α–induced metabolic impairment and enhances microglial response to Aβ pathology
Microglia are the major cell type expressing complement C3a receptor (C3aR) in the brain.
Using a knockin mouse line in which a Td-tomato reporter is incorporated into the …
Using a knockin mouse line in which a Td-tomato reporter is incorporated into the …
Prevention of C5aR1 signaling delays microglial inflammatory polarization, favors clearance pathways and suppresses cognitive loss
MX Hernandez, S Jiang, TA Cole, SH Chu… - Molecular …, 2017 - Springer
Background Pharmacologic inhibition of C5aR1, a receptor for the complement activation
proinflammatory fragment, C5a, suppressed pathology and cognitive deficits in Alzheimer's …
proinflammatory fragment, C5a, suppressed pathology and cognitive deficits in Alzheimer's …
Astrocyte-microglia cross talk through complement activation modulates amyloid pathology in mouse models of Alzheimer's disease
H Lian, A Litvinchuk, ACA Chiang… - Journal of …, 2016 - Soc Neuroscience
Increasing evidence supports a role of neuroinflammation in the pathogenesis of
Alzheimer's disease (AD). Previously, we identified a neuron–glia signaling pathway …
Alzheimer's disease (AD). Previously, we identified a neuron–glia signaling pathway …
Heterozygous CX3CR1 deficiency in microglia restores neuronal β-amyloid clearance pathways and slows progression of Alzheimer's like-disease in PS1-APP mice
SE Hickman, EK Allison, U Coleman… - Frontiers in …, 2019 - frontiersin.org
CX3CR1 is a chemokine receptor expressed on microglia that binds Fractalkine (CX3CL1)
and regulates microglial recruitment to sites of neuroinflammation. Full deletion of CX3CR1 …
and regulates microglial recruitment to sites of neuroinflammation. Full deletion of CX3CR1 …
Blockage of CR1 prevents activation of rodent microglia
H Crehan, J Hardy, J Pocock - Neurobiology of disease, 2013 - Elsevier
The importance of the complement system in Alzheimer's disease (AD) pathogenesis has
been emphasized through recent genome wide association studies. However, the cellular …
been emphasized through recent genome wide association studies. However, the cellular …
Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice
Q Shi, S Chowdhury, R Ma, KX Le, S Hong… - Science translational …, 2017 - science.org
The complement cascade not only is an innate immune response that enables removal of
pathogens but also plays an important role in microglia-mediated synaptic refinement during …
pathogens but also plays an important role in microglia-mediated synaptic refinement during …
[HTML][HTML] CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models
Microglia, the primary immune effector cells in the brain, continually monitor the tissue
parenchyma for pathological alterations and become activated in Alzheimer's disease. Loss …
parenchyma for pathological alterations and become activated in Alzheimer's disease. Loss …
Complement C3 deficiency leads to accelerated amyloid β plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in …
M Maier, Y Peng, L Jiang, TJ Seabrook… - Journal of …, 2008 - Soc Neuroscience
Complement factor C3 is the central component of the complement system and a key
inflammatory protein activated in Alzheimer's disease (AD). Previous studies demonstrated …
inflammatory protein activated in Alzheimer's disease (AD). Previous studies demonstrated …
NFκB-activated astroglial release of complement C3 compromises neuronal morphology and function associated with Alzheimer's disease
H Lian, L Yang, A Cole, L Sun, ACA Chiang… - Neuron, 2015 - cell.com
Abnormal NFκB activation has been implicated in Alzheimer's disease (AD). However, the
signaling pathways governing NFκB regulation and function in the brain are poorly …
signaling pathways governing NFκB regulation and function in the brain are poorly …
Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity
E Czirr, NA Castello, KI Mosher… - Journal of Experimental …, 2017 - rupress.org
Recent genetic evidence supports a link between microglia and the complement system in
Alzheimer's disease (AD). In this study, we uncovered a novel role for the microglial …
Alzheimer's disease (AD). In this study, we uncovered a novel role for the microglial …