Abstract Background Urokinase-type Plasminogen Activator (uPA), a serine protease, plays
a pivotal role in human breast cancer metastasis by mediating the degradation of …

In order to invade and spread, cancer cells must degrade extracellular matrix proteins. This
degradation is catalyzed by the concerted action of several enzymes, including …

BACKGROUND: The urokinase plasminogen activator (uPA) system has been involved in
cancer cell invasion and in metastasis. uPA activity is controlled by its principal inhibitor, the …

Protease nexin-1 (PN-1) belongs to the serpin family of serine protease inhibitors. It is the
phylogenetically closest relative of plasminogen activator inhibitor-1 (PAI-1). Whilst there are …

The serine protease urokinase plasminogen activator (uPA) is causally involved in cancer
invasion and metastasis. Activity of this protease in vivo is controlled principally by two …

Urokinase plasminogen activator (uPA) is a proteolytic enzyme implicated in cancer
invasion and tumor progression. Urokinase PA and its inhibitor (PAI-1) appear to be new …

Urokinase plasminogen activator (uPA) is a multifunctional protein involved in both
extracellular proteolysis and signal transduction. uPA usually mediates its actions while …

Malignant tumors have a capacity to degrade the extracellular matrix (ECM) by controlled
proteolysis. One proteolytic system involved in these processes is the urokinase-type …

Tumor proteases and inhibitors have been associated with paradoxical effects on tumor
progression in preclinical and clinical settings. We previously reported that urokinase (uPA) …

Urokinase-type plasminogen activator (uPA) is a serine protease that is causally involved in
cancer progression, especially invasion and metastasis. Multiple studies have shown that …