Crosstalk exists in mammalian cells between cholesterol trafficking and innate immune
signaling. Apolipoprotein AI (apoA-I), a serum apolipoprotein that induces antiatherogenic …

This review provides a summary of recent research on the role of high-density lipoprotein
(HDL)/apolipoprotein AI cholesterol efflux and immune cell function. Plasma concentrations …

Toll-like receptors (TLRs) and the downstream adaptor molecule myeloid differentiation
factor 88 (MyD88) play an essential role in the innate immune responses. Here, we …

High-density lipoprotein (HDL) mediates reverse cholesterol transport and is known to be
protective against atherosclerosis. In addition, HDL has potent anti-inflammatory properties …

Elevated levels of cholesteryl ester (CE)–enriched apoB containing plasma lipoproteins lead
to increased foam cell formation, the first step in the development of atherosclerosis …

We previously showed that macrophages from macrophage-specific ATP-binding cassette
transporter A1 (ABCA1) knockout (Abca1-M/-M) mice had an enhanced proinflammatory …

Foam cell formation is a hallmark event during atherosclerosis. The current paradigm is that
lipid uptake by scavenger receptor in macrophages initiates the chronic proinflammatory …

Membrane cholesterol modulates a variety of cell signaling pathways and functions. While
cholesterol depletion by high-density lipoproteins (HDLs) has potent anti-inflammatory …

Atherosclerosis was studied in apolipoprotein E (apoE) knockout mice expressing human
apolipoprotein AI (apoA-I) or an apoA-I/apolipoprotein A-II (apoA-II) chimera in which the …

Atherosclerosis, the leading cause of death in developed countries, has been linked to
hypercholesterolemia for decades. More recently, atherosclerotic lesion progression has …