Background DNA methylation (DNAm) is a potential mechanism for propagating the effects
of environmental exposures on child and adolescent mental health. In recent years, this field …

Childhood adversity affects later health, but the underlying molecular mechanisms are
unclear. Although there is some evidence from animal models and case-control studies of a …

Abstract Purpose of Review There is a great deal of interest regarding the biological
embedding of childhood trauma and social exposures through epigenetic mechanisms …

Background Exposure to early-life adversity is known to predict DNA methylation (DNAm)
patterns that may be related to psychiatric risk. However, few studies have investigated …

DNA methylation (DNAm)–an epigenetic process that regulates gene expression–may
represent a mechanism for the biological embedding of early traumatic experiences …

Lasting effects of adversity, such as exposure to childhood adversity (CA) on disease risk,
may be embedded via epigenetic mechanisms but findings from human studies …

Background The effect of gene polymorphisms and promoter methylation, associated with
maladaptive developmental outcomes, vary depending on environmental factors (eg …

Psychiatric disorders are common, complex, and heritable conditions estimated to be the
leading cause of disability worldwide. The last decade of research in genomics of psychiatry …

Objective: DNA methylation has been proposed as an epigenetic mechanism by which early-
life experiences become “embedded” in the genome and alter transcriptional processes to …

Adverse childhood experiences (ACEs), or cumulative childhood stress exposures, such as
abuse, neglect, and household dysfunction, predict later health problems in both the …