We have discussed four specific models which provide different kinds of information about
the requirements for T cell activation. The first utilized a CTL clone designated L3, which is …

In vivo and in vitro, murine peripheral T cells can suppress or" veto" the activation of
cytotoxic T lymphocytes directed against antigens presented by those T cells. This …

The vast majority of mature T cells express the alpha, beta TCR and use this receptor to
recognize Ag in association with MHC determinants. Recent reports indicate that a small …

Publisher Summary This chapter discusses about cytotoxic lymphocytes as effector cells of
cell-mediated immunity. Allograft and tumor immunity are considered to be manifestations of …

A human thymus-dependent differentiation antigen, TH2 was defined by a rabbit anti-human
T cell serum absorbed with autologous B lymphoblasts and leukemic cells bearing T cell …

between lymphocytes and target cells, but complement or serum need not be used. Addition
of alloantibody directed against the target cell, in the absence of added complement, inhibits …

It has become increasingly clear that both the type and intensity of the immune response to
antigen are controlled by a complex series of interactions among different types of T …

Purified human T cells respond proliferatively to allogenic peripheral blood mononuclear
(PBMC) stimulating cells but show no response to murine splenic stimulating cells. Two …

Specific cell-mediated cytotoxicity (CMC) of lymph node cells from immunized C3Hf mice,
against syngeneic C3H/Umc mammary tumor cells, assayed in vitro, is effected by T …

THE mechanisms by which lymphocytes damaged antigenically foreign cells are thought to
be of fundamental importance in the rejection of allografts and neoplastic cells. Studies by …