[HTML][HTML] Leptin, from fat to inflammation: old questions and new insights

M Otero, R Lago, F Lago, FF Casanueva, C Dieguez… - FEBS letters, 2005 - Elsevier
Leptin is 16 kDa adipokine that links nutritional status with neuroendocrine and immune
functions. Initially thought to be a satiety factor that regulates body weight by inhibiting food …

Leptin beyond body weight regulation—current concepts concerning its role in immune function and inflammation

R Lago, R Gomez, F Lago, J Gómez-Reino… - Cellular immunology, 2008 - Elsevier
Leptin, a 16kDa non-glycosylated polypeptide produced primarily by adipocytes and
released into the systemic circulation, exerts a multitude of regulatory functions including …

Leptin as an immunomodulator

C Procaccini, E Jirillo, G Matarese - Molecular aspects of medicine, 2012 - Elsevier
Leptin is an adipocyte-derived hormone/cytokine that links nutritional status with
neuroendocrine and immune functions. In humans, leptin influences energy homeostasis …

Leptin and inflammation

N Iikuni, QL Kwan Lam, L Lu… - Current immunology …, 2008 - ingentaconnect.com
The past few years of research on leptin have provided important information on the link
between metabolism and immune homeostasis. Adipocytes influence not only the endocrine …

Leptin in autoimmune diseases

C Procaccini, V Pucino, CS Mantzoros, G Matarese - Metabolism, 2015 - Elsevier
The past twenty years of research on leptin has provided crucial information on the link
between metabolic state and immune system function. Adipocytes influence not only the …

Leptin: a metabolic hormone that functions like a proinflammatory adipokine.

M Otero, R Lago, R Gómez, F Lago… - Drug news & …, 2006 - europepmc.org
Initially described as a satiety factor with neuroendocrine properties, leptin has been shown
to regulate immune and inflammatory processes. Mainly produced by white adipose tissue …

[PDF][PDF] Role of leptin in immunity

QL Lam, L Lu - Cell Mol Immunol, 2007 - cmi.ustc.edu.cn
Leptin, a protein hormone produced by the adipocytes, has long been recognized to
regulate metabolism, neuroendorine and other physiological functions. Early findings of …

Towards a pro-inflammatory and immunomodulatory emerging role of leptin

M Otero, R Lago, R Gomez, C Dieguez, F Lago… - …, 2006 - academic.oup.com
Leptin is a 16 kDa adipocyte-secreted hormone that regulates weight centrally and links
nutritional status with neuroendocrine and immune function. Since its cloning in 1994 …

Leptin in immunology

G Matarese, S Moschos… - The Journal of Immunology, 2005 - journals.aai.org
Leptin is an adipokine which conveys information on energy availability. In humans, leptin
influences energy homeostasis and regulates neuroendocrine function primarily in states of …

Leptin in the interplay of inflammation, metabolism and immune system disorders

V Abella, M Scotece, J Conde, J Pino… - Nature Reviews …, 2017 - nature.com
Leptin is one of the most relevant factors secreted by adipose tissue and the forerunner of a
class of molecules collectively called adipokines. Initially discovered in 1994, its crucial role …