Triiodothyronine Potentiates Vasorelaxation via PKG/VASP Signaling in Vascular Smooth Muscle Cells
Abstract Background/Aims: Vascular relaxation caused by Triiodothyronine (T3) involves
direct activation of endothelial cells (EC) and vascular smooth muscle cells (VSMC) …
direct activation of endothelial cells (EC) and vascular smooth muscle cells (VSMC) …
Triiodothyronine reduces vascular dysfunction associated with hypertension by attenuating protein kinase g/vasodilator-stimulated phosphoprotein signaling
MA Carrillo-Sepulveda, A Panackal, R Maracheril… - … of Pharmacology and …, 2019 - ASPET
Vascular dysfunction associated with hypertension comprises hypercontractility and
impaired vasodilation. We have previously demonstrated that triiodothyronine (T3), the …
impaired vasodilation. We have previously demonstrated that triiodothyronine (T3), the …
Thyroid hormone stimulates NO production via activation of the PI3K/Akt pathway in vascular myocytes
MA Carrillo-Sepúlveda, GS Ceravolo… - Cardiovascular …, 2010 - academic.oup.com
Aims Thyroid hormone (TH) rapidly relaxes vascular smooth muscle cells (VSMCs).
However, the mechanisms involved in this effect remain unclear. We hypothesize that TH …
However, the mechanisms involved in this effect remain unclear. We hypothesize that TH …
Hyperthyroidism enhances endothelium-dependent relaxation in the rat renal artery
E Büssemaker, R Popp, B Fisslthaler… - Cardiovascular …, 2003 - academic.oup.com
Objective: Hyperthyroidism has pronounced effects on vascular function and endothelium-
dependent relaxation. The aim of the present study was to identify mechanisms underlying …
dependent relaxation. The aim of the present study was to identify mechanisms underlying …
Emerging role of angiotensin type 2 receptor (AT2R)/Akt/NO pathway in vascular smooth muscle cell in the hyperthyroidism
MA Carrillo-Sepúlveda, GS Ceravolo, CR Furstenau… - PloS one, 2013 - journals.plos.org
Hyperthyroidism is characterized by increased vascular relaxation and decreased vascular
contraction and is associated with augmented levels of triiodothyronine (T3) that contribute …
contraction and is associated with augmented levels of triiodothyronine (T3) that contribute …
Acute effects of thyroid hormone on vascular smooth muscle
K Ojamaa, JD Klemperer, I Klein - Thyroid, 1996 - liebertpub.com
The enhanced cardiovascular hemodynamics associated with triiodo-l-thyronine (T3)
treatment is in part mediated by a decrease in systemic vascular resistance. To determine …
treatment is in part mediated by a decrease in systemic vascular resistance. To determine …
Noncanonical thyroid hormone receptor α action mediates arterial vasodilation
D Geist, GS Hönes, J Gassen, H Kerp… - …, 2021 - academic.oup.com
Context Hypothyroidism impairs cardiovascular health and contributes to endothelial
dysfunction with reduced vasodilation. How 3, 5, 3′-triiodothyronine (T3) and its receptors …
dysfunction with reduced vasodilation. How 3, 5, 3′-triiodothyronine (T3) and its receptors …
[HTML][HTML] Thyrotropin induces atherosclerosis by upregulating large conductance Ca2+-activated K+ channel subunits
L Xie, Q You, J Mao, F Wu, C Xia, R Hai, Y Wei… - Molecular and Cellular …, 2024 - Elsevier
Hypothyroidism is associated with elevated levels of serum thyrotropin (TSH), which have
been shown to promote abnormal proliferation of vascular smooth muscle cells and …
been shown to promote abnormal proliferation of vascular smooth muscle cells and …
PKCα mediates acetylcholine-induced activation of TRPV4-dependent calcium influx in endothelial cells
RK Adapala, PK Talasila, IN Bratz… - American Journal …, 2011 - journals.physiology.org
Transient receptor potential vanilloid channel 4 (TRPV4) is a polymodally activated
nonselective cationic channel implicated in the regulation of vasodilation and hypertension …
nonselective cationic channel implicated in the regulation of vasodilation and hypertension …
Acute effects of triiodothyronine on endothelial function in human subjects
R Napoli, V Guardasole, V Angelini… - The Journal of …, 2007 - academic.oup.com
Context: Thyroid hormone regulates several cardiovascular functions, and low T3 levels are
frequently associated with cardiovascular diseases. Whether T3 exerts any acute and direct …
frequently associated with cardiovascular diseases. Whether T3 exerts any acute and direct …