Numb is an evolutionary conserved protein that plays critical roles in cell fate determination.
Mammalian Numb displays a higher degree of structural complexity compared to the …

LNX was originally cloned as a Numb PTB-binding molecule, and it was subsequently found
to act as a RING finger-type E3 ubiquitin ligase for the ubiquitylation and degradation of …

The histone methyltransferase DOT1L methylates lysine 79 (K79) on histone H3 and is
involved in Mixed Lineage Leukemia (MLL) fusion leukemogenesis; however, its role in …

Numb functions as an oncosuppressor by inhibiting Notch signaling and stabilizing p53.
This latter effect depends on the interaction of Numb with Mdm2, the E3 ligase that …

Nuclear domain 10 (ND10), also referred to as nuclear bodies, are discrete
interchromosomal accumulations of several proteins including promyelocytic leukemia …

Abstract P53-binding protein 1 (53BP1) regulates the double-strand break (DSB) repair
pathway choice. A recently identified 53BP1-binding protein Tudor-interacting repair …

The cell fate determinant Numb is aberrantly expressed in cancer. Numb is alternatively
spliced, with one isoform containing a long proline‐rich region (PRRL) compared to the …

Nuclear receptor binding SET domain protein 3 (NSD3), a gene located within the 8p11-p12
amplicon frequently detected in human cancers, encodes a chromatin modulator and an …

Members of the bromodomain and extra-terminal domain (BET) family of proteins
(bromodomain-containing (BRD) 2, 3, 4, and T) are widely expressed and highly conserved …

Abstract Recurring chromosomal translocation t (10; 17)(p15; q21) present in a subset of
human acute myeloid leukemia (AML) patients creates an aberrant fusion gene termed …