Inhibitors of bromodomain and extraterminal domain (BET) proteins, a family of chromatin
reader proteins, have therapeutic efficacy against various malignancies. However, the …

Cancer stem cells (CSCs) are a subpopulation of cancer that can self-renew and
differentiate into large tumor masses. Evidence accumulated to date shows that CSCs affect …

Background and Aims Alternative splicing (AS) is a key step that increases the diversity and
complexity of the cancer transcriptome. Recent evidence has highlighted that AS has an …

Messenger RNAs with premature translation termination codons (PTCs) are degraded by
nonsense-mediated mRNA decay (NMD). In mammals, PTCs are discriminated from …

Triple-negative breast cancer (TNBC) is a heterogeneous malignancy in women. It is
associated with poor prognosis, aggressive malignant behavior, and limited treatment …

NumbL, or Numb-like, is a close homologue of Numb, and is part of an evolutionary
conserved protein family implicated in some important cellular processes. Numb is a protein …

Nrf2 signaling is vital for protecting cells against oxidative stress. However, its
hyperactivation is frequently found in liver cancer through excessive build‐up of …

Triple-negative breast cancer (TNBC), an aggressive subtype of breast cancer with higher
rates of early relapse and metastasis, is frequently associated with aberrant activation of …

Recent studies suggest that BET inhibitors are effective anti-cancer therapeutics. Here we
show that BET inhibitors are effective against murine primary mammary tumors, but not …

The biological antagonism between Notch and Numb controls the proliferative/differentiative
balance in development and homeostasis. Although altered Notch signaling has been …