Abstract p53 is frequently wild type (wt) in diffuse large B-cell lymphoma (DLBCL)
associated with t (14; 18)(q32; q21) that overexpresses BCL2. Nutlin-3a is a small molecule …

Glioblastoma (GBM) is the most lethal type of human brain cancer, where deletions and
mutations in the tumour suppressor gene PTEN (phosphatase and tensin homolog) are …

Hu antigen R (HuR) is a central RNA‐binding protein regulating cell dedifferentiation,
proliferation, and survival, which are well‐established hallmarks of cancer. HuR is frequently …

Tumor-initiating stem-like cells (TICs) are defective in maintaining asymmetric cell division
and responsible for tumor recurrence. Cell-fate-determinant molecule NUMB-interacting …

NUMB, a plasma membrane-associated protein originally described in Drosophila, is
involved in determining cell function and fate during early stages of development. It is …

Nuclear structures ND10/PML NBs are linked to multiple processes, including the
maintenance of intranuclear homeostasis by sequestering proteins into “nuclear depot.” This …

Summary We developed Split DamID (SpDamID), a protein complementation version of
DamID, to mark genomic DNA bound in vivo by interacting or juxtapositioned transcription …

Metastatic melanoma remains a mostly incurable disease. Although newly approved
targeted therapies are efficacious in a subset of patients, resistance and relapse rapidly …

Abstract Rad50/Mre11/NBS1 (R/M/N) is a multi‐functional protein complex involved in DNA
repair, cell cycle checkpoint activation, DNA replication and replication block‐induced …

Tudor domain–containing proteins (TDRDs), which recognize and bind to methyl-
lysine/arginine residues on histones and non-histone proteins, play critical roles in …