To complement traditional antivirals, natural compounds that act via host targets and present
high barriers to resistance are of increasing interest. In the work reported here, we detected …

Harringtonine (HT) and homoharringtonine (HHT), alkaloid esters isolated from the genus
Cephalotaxus, exhibit antitumor activity. A semisynthetic HHT has been approved for …

Abstract Phyllanthus urinaria Linnea (Euphorbiaceae) is a commonly used traditional
medicinal plant in oriental countries and has been reported to possess various biological …

Honokiol is a pleiotropic natural compound isolated from Magnolia and has multiple
biological and clinically relevant effects, including anticancer and antimicrobial function …

Homoharringtonine (HHT), an approved anti-leukemic alkaloid, has been reported
effectively in many types of tumor cells. However, its effect on melanoma cells has not been …

A ionization technique in mass spectrometry called Direct Analysis in Real Time Mass
Spectrometry (DART TOF-MS) coupled with a Direct Binding Assay was used to identify and …

Herpes genitalis, caused by HSV-2, is an incurable genital ulcerative disease transmitted by
sexual intercourse. The virus establishes life-long latency in sacral root ganglia and reported …

Cepharanthine (CEP) is a naturally occurring isoquinoline alkaloid extracted from Stephania
cepharantha Hayata. Although its underlying molecular mechanism is not fully understood …

To counteract the serious health threat posed by known and novel viral pathogens, drugs
that target a variety of viruses through a common mechanism have attracted recent attention …

The highly pathogenic avian influenza H5N1 virus has become a worldwide public health
threat, and current antiviral therapies have limited activity against the emerging, resistant …