Hyperphosphorylated tau in neurites surrounding β‐amyloid (βA) deposits, as revealed with
phospho‐specific anti‐tau antibodies, are found in amyloid precursor protein (APP) Tg2576 …

Hyperphosphorylation and accumulation of tau in neurons (and glial cells) is one the main
pathologic hallmarks in Alzheimer's disease (AD) and other tauopathies, including Pick's …

Hyperphosphorylation and accumulation of tau in neurons (and glial cells) is one the main
pathologic hallmarks in Alzheimer's disease (AD) and other tauopathies, including Pick's …

To clarify how Aβ deposits induce secondary tauopathy, the presence of phosphorylated tau,
glycogen synthase kinase 3α (GSK3α), GSK3β, cyclin-dependent kinase 5 (CDK5), mitogen …

Previous studies of Aβ-induced neuronal damage of hippocampal cells in culture have
provided strong evidence that deregulation of the Cdk5/p35 kinase system is involved in the …

Several novel transgenic mouse models expressing different mutant APPs in combination
with mutant PS1 have been developed. These models have been analyzed to investigate …

The temporal association between oxidative stress and the hallmark pathologies of
Alzheimer disease (AD) demonstrates that oxidative stress is among the earliest events in …

The abnormal hyperphosphorylation of tau in Alzheimer's disease (AD) has been proposed
to involve the extracellular-signal-regulated protein kinase (ERK) of the mitogen-activated …

Calcium/calmodulin-dependent kinase II (α-and β-CaM kinase II), and phosphorylated
mitogen-activated extracellular signal-regulated protein kinase (MAPK/ERK-P) …

It is known that in the nervous tissue β-amyloid overproduction and its extracellular or
intracellular deposition can activate mitogen-activated protein kinases involved in tau …