New oxadiazole and pyrazoline derivatives as anti-proliferative agents targeting EGFR-TK: design, synthesis, biological evaluation and molecular docking study
Two new series of oxadiazole and pyrazoline derivatives were designed and synthesized as
promising EGFR-TK inhibitors. The in vitro antiproliferative activity was studied against three …
promising EGFR-TK inhibitors. The in vitro antiproliferative activity was studied against three …
New series of isoxazole derivatives targeting EGFR-TK: Synthesis, molecular modeling and antitumor evaluation
New series of isoxazole derivatives were synthesized and evaluated for in vitro antitumor
activity against HepG2, MCF-7 and HCT-116 cancer cells. Results showed that 4b and 25a …
activity against HepG2, MCF-7 and HCT-116 cancer cells. Results showed that 4b and 25a …
Novel Pyrazoloquinolin-2-ones: Design, synthesis, docking studies, and biological evaluation as antiproliferative EGFR-TK inhibitors
Two new series of diethyl 2-[2-(substituted-2-oxo-1, 2-dihydroquinolin-4-yl) hydrazono]-
succinates 6a-g and 1-(2-oxo-1, 2-dihydroquinolin-4-yl)-1H-pyrazoles 7a-f have been …
succinates 6a-g and 1-(2-oxo-1, 2-dihydroquinolin-4-yl)-1H-pyrazoles 7a-f have been …
Design, synthesis and in vitro anti-proliferative activity of 4, 6-quinazolinediamines as potent EGFR-TK inhibitors
4-Anilino-6-substituted-quinazolines were designed, synthesized and evaluated for EGFR-
TK and tumor growth inhibitory activities. The target compounds were designed with …
TK and tumor growth inhibitory activities. The target compounds were designed with …
Design, synthesis and biological evaluation of a new series of thiazolyl-pyrazolines as dual EGFR and HER2 inhibitors
Epidermal growth factor receptor (EGFR, also known as HER1) and HER2, prominent
members of receptor tyrosine kinase (RTK) superfamily, have been reported as diagnostic or …
members of receptor tyrosine kinase (RTK) superfamily, have been reported as diagnostic or …
Discovery of 3, 3 a, 4, 5-tetrahydro-2 H-benzo [g] indazole containing quinoxaline derivatives as novel EGFR/HER-2 dual inhibitors
X Zong, J Cai, J Chen, C Sun, L Li, M Ji - RSC Advances, 2015 - pubs.rsc.org
In the present study, twenty-five pyrazole–quinoxaline derivatives (4a–4y) were designed
and synthesized, and their biological activity as potential EGFR or HER-2 kinase inhibitors …
and synthesized, and their biological activity as potential EGFR or HER-2 kinase inhibitors …
Novel 2-(5-Aryl-4, 5-dihydropyrazol-1-yl) thiazol-4-one as EGFR inhibitors: synthesis, biological assessment and molecular docking insights
Introduction Epidermal growth factor receptor (EGFR) regulates several cell functions which
include cell growth, survival, multiplication, differentiation, and apoptosis. Currently, EGFR …
include cell growth, survival, multiplication, differentiation, and apoptosis. Currently, EGFR …
New Thiazolyl-Pyrazoline derivatives as potential dual EGFR/HER2 inhibitors: design, synthesis, anticancer activity evaluation and in silico study
A new series of thiazolyl-pyrazoline derivatives (4a–d, 5a–d 6a, b, 7a–d, 8a, b, and 10a, b)
have been designed and synthesized through the combination of thiazole and pyrazoline …
have been designed and synthesized through the combination of thiazole and pyrazoline …
Design, synthesis, biological evaluation and docking study of novel quinazoline derivatives as EGFR-TK inhibitors
H Jin, BX Wu, Q Zheng, CH Hu, XZ Tang… - Future Medicinal …, 2021 - Taylor & Francis
Background: Quinazoline-based compounds have been proved effective in the treatment of
cancers for years. Materials & methods: The structural features of several inhibitors of EGFR …
cancers for years. Materials & methods: The structural features of several inhibitors of EGFR …
Harnessing molecular hybridization approach to discover novel quinoline EGFR-TK inhibitors for cancer treatment
N Ryad, AA Elmaaty, IM Ibrahim… - Future Medicinal …, 2024 - Taylor & Francis
Aim: Using molecular hybridization approach, novel 18 quinoline derivatives (6a–11) were
designed and synthesized as EGFR-TK inhibitors. Materials & methods: The antiproliferative …
designed and synthesized as EGFR-TK inhibitors. Materials & methods: The antiproliferative …
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