Skeletal muscle insulin resistance entails dysregulation of both glucose and fatty acid
metabolism. This study examined whether a combined intervention of physical activity and …

Obesity is characterized by excessive rates of plasma fatty acid mobilization and uptake,
which play a key role in mediating insulin resistance. While weight loss via diet‐only or a …

Background: Obesity may be associated with a lowered use of fat as a fuel, which may
contribute to the enlarged adipose tissue stores. Aim: The aim of the present study was to …

Older, obese, and sedentary individuals are at high risk of developing diabetes and
cardiovascular disease. Exercise training improves metabolic anomalies associated with …

Disturbances in fat oxidation have been associated with an increased risk of obesity and
metabolic disorders such as insulin resistance. There is large intersubject variability in the …

Muscle fatty acid (FA) metabolism is impaired in obesity and insulin resistance, reflected by
reduced rates of FA oxidation and accumulation of lipids. It has been suggested that …

Interventions aimed at increasing fat metabolism could potentially reduce the symptoms of
metabolic diseases such as obesity and type 2 diabetes and may have tremendous clinical …

Regular physical exercise is of the utmost importance in the treatment of obesity because
exercise is one of the factors determining long-term weight maintenance in weight reduction …

ABSTRACT VENABLES, MC and AE JEUKENDRUP. Endurance Training and Obesity:
Effect on Substrate Metabolism and Insulin Sensitivity. Med. Sci. Sports Exerc., Vol. 40, No …

Background: Energy restriction is known to induce a decline in fat oxidation during the
postdiet period. Reduced fat oxidation may contribute to weight regain. Objective: The …