Free radical formation, abnormalities in iron and copper distribution, and metal-catalyzed
oxidation have all been noted in Alzheimer disease and are thought to play an important …

Metal-catalyzed hydroxyl radicals are potent mediators of cellular injury, affecting every
category of macromolecule, and are central to the oxidative injury hypothesis of Alzheimer …

The role of oxidative stress in the pathogenesis of Alzheimer disease has gone from
epiphenomena to phenomena. This transition, from disregarded to accepted theory, started …

Damage from free radicals has been demonstrated in susceptible neuronal populations in
cases of Alzheimer disease. In this study, we investigated whether iron, a potent source of …

Many lines of evidence indicate that oxidative stress is one of the earliest events in the
genesis of Alzheimer's disease (AD). Iron is a transition metal capable of generating …

Oxidative damage to every class of biological macromolecule has been characterized in
Alzheimer's disease. Abnormalities in iron and copper metabolism are also being implicated …

Central to oxidative damage in Alzheimer disease is the production of metal-catalyzed
hydroxyl radicals that damage every category of macromolecule. Studies on redox …

Oxidative damage of biological macromolecules is a hallmark of most neurodegenerative
disorders such as Alzheimer, Parkinson and diffuse Lewy body diseases. Another important …

Research in Alzheimer disease has recently demonstrated compelling evidence on the
importance of oxidative processes in its pathogenesis. Cellular changes show that oxidative …

Iron is both essential for maintaining a spectrum of metabolic processes in the central
nervous system and elsewhere, and potent source of reactive oxygen species. Redox …