Iron is a trace metal element necessary to maintain life and is also involved in a variety of
biological processes. Aging refers to the natural life process in which the physiological …

Iron is an essential trace metal for almost all organisms, including human; however,
oxidative stress can easily be caused when iron is in excess, producing toxicity to the human …

Iron is an essential element that participates in numerous cellular processes. Any disruption
of iron homeostasis leads to either iron deficiency or iron overload, which can be detrimental …

Iron is indispensable for normal body functions across species because of its critical roles in
red blood cell function and many essential proteins and enzymes required for numerous …

Iron is the most abundant trace element in the human body. It is well known that iron is an
important component of hemoglobin involved in the transport of oxygen. As a component of …

Brain iron is tightly regulated by a multitude of proteins to ensure homeostasis. Iron
dyshomeostasis has become a molecular signature associated with aging which is …

The incidence of neurological diseases, such as Parkinson's disease, Alzheimer's disease
and stroke, is increasing. An increasing number of studies have correlated these diseases …

New findings obtained during the past years, especially the discovery of mutations in the
genes associated with brain iron metabolism, have provided key insights into the …

Alzheimer's disease (AD) is the most common neurodegenerative disease worldwide. β-
amyloid plaque (Aβ) deposition and hyperphosphorylated tau, as well as dysregulated …

Brain iron homeostasis is increasingly recognized as a potential target for the development
of drug therapies for aging‐related disorders. Dysregulation of iron metabolism associated …