VEGF-B: a survival, or an angiogenic factor?

X Li, C Lee, Z Tang, F Zhang, P Arjunan… - Cell adhesion & …, 2009 - Taylor & Francis
Despite its early discovery and high sequence homology to the other VEGF family members,
the biological function of VEGF-B remained debatable for a long time, and VEGF-B has …

VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis

F Zhang, Z Tang, X Hou… - Proceedings of the …, 2009 - National Acad Sciences
VEGF-B, a homolog of VEGF discovered a long time ago, has not been considered an
important target in antiangiogenic therapy. Instead, it has received little attention from the …

VEGF-B inhibits apoptosis via VEGFR-1–mediated suppression of the expression of BH3-only protein genes in mice and rats

Y Li, F Zhang, N Nagai, Z Tang… - The Journal of …, 2008 - Am Soc Clin Investig
Despite its early discovery and high sequence homology to the other VEGF family members,
the biological functions of VEGF-B remain poorly understood. We revealed here a novel …

Complicated life, complicated VEGF-B

X Li, A Kumar, F Zhang, C Lee, Z Tang - Trends in molecular medicine, 2012 - cell.com
No other member of the VEGF (vascular endothelial growth factor) family has been as
mysterious as VEGF-B. Notwithstanding its name, VEGF-B can hardly be regarded as a …

VEGF: once regarded as a specific angiogenic factor, now implicated in neuroprotection

E Storkebaum, D Lambrechts, P Carmeliet - Bioessays, 2004 - Wiley Online Library
Both blood vessels and nerves are guided to their target. Vascular endothelial growth factor
(VEGF) A is a key signal in the induction of vessel growth (a process termed angiogenesis) …

Delineating multiple functions of VEGF-A in the adult brain

T Licht, E Keshet - Cellular and molecular life sciences, 2013 - Springer
Vascular endothelial growth factor-A (abbreviated throughout this review as VEGF) is mostly
known for its angiogenic activity, for its activity as a vascular permeability factor, and for its …

VEGF in biological control

EC Breen - Journal of cellular biochemistry, 2007 - Wiley Online Library
Vascular endothelial growth factor A (VEGF‐A) belongs to a family of heparin binding growth
factors that include VEGF‐B, VEGF‐C, VEGF‐D, and placental‐like growth factor (PLGF) …

VEGF-B: a thing of beauty

X Li - Cell research, 2010 - nature.com
More than a decade ago, when we first embarked on our journey to delineate the biological
function of vascular endothelial growth factor B (VEGF-B), we had a hard time …

VEGF, a prosurvival factor, acts in concert with TGF-β1 to induce endothelial cell apoptosis

G Ferrari, G Pintucci, G Seghezzi… - Proceedings of the …, 2006 - National Acad Sciences
VEGF and TGF-β1 are potent angiogenesis inducers with opposing effects on endothelial
cells. TGF-β1 induces apoptosis; VEGF protects endothelial cells from apoptosis. We found …

VEGF signaling: Role in angiogenesis and beyond

P Shaw, SKD Dwivedi, R Bhattacharya… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Angiogenesis is a crucial process for tissue development, repair, and tumor survival.
Vascular endothelial growth factor (VEGF) is a key driver secreted by cancer cells …