Many lines of evidence support the hypothesis that connexins form a family of tumor‐
suppressor genes. Transfection of connexin43 (Cx43) into rat C6 glioma cells have revealed …

Connexins (cx), structural components of gap junction, are believed to play a role in the
regulation of cell proliferation and suppression of the neoplastic phenotype. We used human …

Gap junctions are cellular structures which permit direct exchanges of small molecules from
cytoplasm to cytoplasm in most of the cells of metazoan organisms. For four decades, it has …

Abstract Connexin 43 (Cx43), the most widely expressed gap junction protein, has a role in
regulation of cell growth. In this study, we demonstrate that the point mutations F199L …

Evidence is accumulating that connexin (Cx) genes form a family of tumor-suppressor
genes. Our long-standing study revealed that, in almost all tumors, some abnormality in gap …

Connexin genes exert negative growth control when transfected into various types of tumor
cell lines. We previously demonstrated that connexin 26 (Cx26) suppresses in vitro and in …

There is a large body of evidence suggesting the connexin gap junction proteins appear to
act as tumor suppressors, and their tumor inhibitory effect is usually attributed to their main …

Our laboratory has previously reported that transfection of a connexin26 (Cx26) gene, but
not connexin40 nor connexin43 (Cx43), into HeLa cells expressing no detectable level of …

Connexins, the structural components of gap junctions, control cell growth and differentiation
and are believed to belong to a family of tumour suppressor genes. Studies on connexin …

The Connexin (Cx) gene family acts as a tumor suppressor. However, it is unclear whether
the tumor-suppressing activity acquired by Cx gene transfection is mainly due to the …