The spread of resistant organisms is producing a human health crisis, as we are witnessing
the emergence of pathogens resistant to all available antibiotics. An increase in chronic …

The spread of resistant bacteria, leading to untreatable infections, is a major public health
threat but the pace of antibiotic discovery to combat these pathogens has slowed down …

The widespread emergence of antibiotic-resistant pathogens poses a severe threat to public
health. This problem becomes even worse with a coincident decline in the supply of new …

We are experiencing an antimicrobial resistance (AMR) crisis, brought on by the drying up of
the antibiotic discovery pipeline and the resulting unchecked spread of resistant pathogens …

The pharmaceutical industry has historically relied on nature to provide compounds for
antibacterial drug discovery. In recent years, several pharmaceutical companies have …

Antibiotic discovery is in crisis. Despite a growing need for new drugs resulting from the
increasing number of multi-antibiotic-resistant pathogens, there have been only a handful of …

The dwindling supply of new antibiotics largely reflects regulatory and commercial
challenges, but also a failure of discovery. In the 1990s the pharmaceutical industry …

Introduction: Natural products have long been instrumental for discovering antibiotics, but
many pharmaceutical companies abandoned this field and new antibiotics declined. In …

New antibiotics are necessary to treat microbial pathogens that are becoming increasingly
resistant to available treatment. Despite the medical need, the number of newly approved …

Bacteria are becoming increasingly resistant to currently used antibiotics. At the same time,
little progress has been made in discovering new antibacterial drugs to combat resistant …