Exogenous H2O2 is widely applied to cardiovascular tissues in order to elicit oxidant-
dependent responses relevant to signalling and disease. Lower levels of endogenous H2O2 …

Increased production of reactive oxygen species (ROS) has been implicated in the
pathogenesis of cardiovascular diseases. Enzymatic systems such as the mitochondrial …

Hydrogen peroxide (H2O2) is a well-documented component of living cells. It plays
important roles in host defense and oxidative biosynthetic reactions. In addition there is …

Numerous studies have demonstrated the ability of a variety of vascular cells, including
endothelial cells, smooth muscle cells, and fibroblasts, to produce reactive oxygen species …

Significance: Oxidants were once principally considered perpetrators of injury and disease.
However, this has become an antiquated view, with cumulative evidence showing that the …

Cells within the vessel wall have the capacity to produce a variety of reactive oxygen
species (ROS: superoxide anion, hydrogen peroxide [H2O2], hydroxyl radical, etc). 1–3 In …

Intracellular generation of reactive oxygen species (ROS) is an inescapable consequence of
aerobic metabolism. Although some of these oxygen-derived metabolites are well …

Abstract Hydrogen peroxide (H2O2) is widely regarded as a cytotoxic agent whose levels
must be minimized by the action of antioxidant defence enzymes. In fact, H2O2 is poorly …

Oxidative stress represents excessive intracellular levels of reactive oxygen species (ROS),
which plays a major role in the pathogenesis of cardiovascular disease. Besides having a …

Abstract Paracrine superoxide (O 2•−) and hydrogen peroxide (H 2 O 2) signaling critically
depends on these substances' concentrations, half-lives and transport ranges in …