Introduction The identification of potential breast cancer stem cells is of importance as the
characteristics of stem cells suggest that they are resistant to conventional forms of therapy …

The theory that cancer may be originated and sustained by a small proportion of stem-like,
self-renewing cells (termed 'cancer stem cells') has gained support in recent years. Breast …

Introduction Breast cancer is thought to arise in mammary epithelial stem cells. There is,
therefore, a large amount of interest in identifying these cells. The breast is a complex tissue …

The concept of cancer stem cells responsible for tumour origin, maintenance, and resistance
to treatment has gained prominence in the field of breast cancer research. The therapeutic …

Background Breast cancer stem cells (BCSCs) can be enriched by culturing of cells in non-
adherent non-differentiating conditions. However, culturing mammospheres from primary …

Evidence that supports the existence of a tumour stem cell for breast cancer has given fresh
impetus to the search for an adult mammary epithelial stem cell in the normal breast. Such a …

There is substantial evidence that many cancers, including breast cancer, are driven by a
population of cells that display stem cell properties. These cells, termed cancer stem cells …

The concept of stem-like cells in cancer has been gaining currency over the last decade or
so since evidence for stem cell activity in human leukaemia and solid tumours, including …

Introduction The phenotypic and functional differences between cells that initiate human
breast tumors (cancer stem cells) and those that comprise the tumor bulk are difficult to study …

Background Tumorigenic breast cancer cells that express high levels of CD44 and low or
undetectable levels of CD24 (CD44>/CD24>/low) may be resistant to chemotherapy and …