Regulation of pathogenesis and immunity in helminth infections

RM Maizels, EJ Pearce, D Artis… - Journal of Experimental …, 2009 - rupress.org
Helminths are multicellular eukaryotic parasites that infect over one quarter of the world's
population. Through coevolution with the human immune system, these organisms have …

[HTML][HTML] Regulation of the host immune system by helminth parasites

RM Maizels, HJ McSorley - Journal of Allergy and Clinical Immunology, 2016 - Elsevier
Helminth parasite infections are associated with a battery of immunomodulatory
mechanisms that affect all facets of the host immune response to ensure their persistence …

Immune regulation during helminth infections

NM Girgis, UM Gundra, P Loke - PLoS pathogens, 2013 - journals.plos.org
Helminth is a nonphylogenetic term that refers to multicellular animals (or metazoans) that
have adopted a parasitic lifestyle in mammalian hosts. They are more commonly referred to …

Immune regulation by helminth parasites: cellular and molecular mechanisms

RM Maizels, M Yazdanbakhsh - Nature Reviews Immunology, 2003 - nature.com
Immunology was founded by studying the body's response to infectious microorganisms,
and yet microbial prokaryotes only tell half the story of the immune system. Eukaryotic …

Protective immune mechanisms in helminth infection

RM Anthony, LI Rutitzky, JF Urban Jr… - Nature Reviews …, 2007 - nature.com
Important insights have recently been gained in our understanding of how host immune
responses mediate resistance to parasitic helminths and control associated pathological …

Helminth infections and host immune regulation

HJ McSorley, RM Maizels - Clinical microbiology reviews, 2012 - Am Soc Microbiol
Helminth parasites infect almost one-third of the world's population, primarily in tropical
regions. However, regions where helminth parasites are endemic record much lower …

Helminth parasites–masters of regulation

RM Maizels, A Balic, N Gomez‐Escobar… - Immunological …, 2004 - Wiley Online Library
Immune regulation by parasites is a global concept that includes suppression, diversion,
and conversion of the host immune response to the benefit of the pathogen. While many …

Regulation of allergy and autoimmunity in helminth infection

MS Wilson, RM Maizels - Clinical reviews in allergy & immunology, 2004 - Springer
Parasitic infections are a major theme in the “hygiene hypothesis”, as allergies and
autoimmune diseases are less prevalent in countries with higher burdens of helminths and …

[HTML][HTML] Helminth parasites and immune regulation

PH Gazzinelli-Guimaraes, TB Nutman - F1000Research, 2018 - ncbi.nlm.nih.gov
Helminth parasites are complex metazoans that belong to different taxonomic families but
that collectively share the capacity to downregulate the host immune response directed …

Diversity and dialogue in immunity to helminths

JE Allen, RM Maizels - Nature Reviews Immunology, 2011 - nature.com
The vertebrate immune system has evolved in concert with a broad range of infectious
agents, including ubiquitous helminth (worm) parasites. The constant pressure of helminth …