The quest for the initial lesion in idiopathic pulmonary fibrosis: gene expression differences in IPF fibroblasts

O Eickelberg, GJ Laurent - American journal of respiratory cell and …, 2010 - atsjournals.org
Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal disorder due to its unresolved
pathogenesis and limited responsiveness to currently available therapies. It is characterized …

[HTML][HTML] Genomic phenotype of non-cultured pulmonary fibroblasts in idiopathic pulmonary fibrosis

MC Emblom-Callahan, MK Chhina, OA Shlobin… - Genomics, 2010 - Elsevier
Activated fibroblasts are the central effector cells of the progressive fibrotic process in
idiopathic pulmonary fibrosis (IPF). Characterizing the genomic phenotype of isolated …

Genetic background of idiopathic pulmonary fibrosis

S Santangelo, S Scarlata, A Zito, D Chiurco… - Expert review of …, 2013 - Taylor & Francis
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease characterized by
progressive fibrosing interstitial pneumonia. The histological pattern, which displays dense …

Back to the future: historical perspective on the pathogenesis of idiopathic pulmonary fibrosis

PW Noble, RJ Homer - American journal of respiratory cell and …, 2005 - atsjournals.org
One of the more challenging areas of pulmonary medicine remains elucidating the
pathogenesis of idiopathic pulmonary fibrosis (IPF). IPF is a devastating disease process …

Central lung gene expression associates with myofibroblast features in idiopathic pulmonary fibrosis

Y Huang, R Guzy, SF Ma… - BMJ Open …, 2023 - bmjopenrespres.bmj.com
Rationale Contribution of central lung tissues to pathogenesis of idiopathic pulmonary
fibrosis (IPF) remains unknown. Objective To ascertain the relationship between cell types of …

Developmental pathways in the pathogenesis of lung fibrosis

D Chanda, E Otoupalova, SR Smith, T Volckaert… - Molecular aspects of …, 2019 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a progressive and terminal lung disease with no known
cure. IPF is a disease of aging, with median age of diagnosis over 65 years. Median survival …

The epithelial/fibroblastic pathway in the pathogenesis of idiopathic pulmonary fibrosis: tying loose ends

M Selman, A Pardo - American journal of respiratory cell and …, 2003 - search.proquest.com
The prevailing hypothesis regarding the pathogenesis of the fibrotic lung disorders supports
a sequence of events initiated by a lung injury, which is followed by an inflammatory …

Idiopathic pulmonary fibrosis: New insights into classification and pathogenesis usher in a new era in therapeutic approaches

PW Noble - American journal of respiratory cell and molecular …, 2003 - search.proquest.com
Idiopathic pulmonary fibrosis (IPF) is a fascinating and poorly understood disease with
devastating consequences to those afflicted that has undergone several revisions in the last …

Pathogenesis of idiopathic pulmonary fibrosis

PJ Wolters, HR Collard, KD Jones - Annual Review of Pathology …, 2014 - annualreviews.org
Idiopathic pulmonary fibrosis (IPF) is a fibrosing interstitial lung disease associated with
aging that is characterized by the histopathological pattern of usual interstitial pneumonia …

The interplay of the genetic architecture, aging, and environmental factors in the pathogenesis of idiopathic pulmonary fibrosis

A Pardo, M Selman - American journal of respiratory cell and …, 2021 - atsjournals.org
Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing lung disease of indeterminate
etiology and limited therapeutic options. The initiation, development, and progression of IPF …