The multidrug resistance (MDR1) gene product P-glycoprotein is a membrane bound protein
that functions as an ATP-dependent efflux pump, transporting exogenous and endogenous …

Multidrug‐resistance (MDR) phenotype is a serious limitation to the effective
chemotherapeutic treatment of many cancer types, including leukemia. One of the most …

We investigated the association between the MDR1 C3435T polymorphism and P-
glycoprotein function of leukemic blasts as well as clinical outcomes in 200 patients with …

Multidrug resistance is an important mechanism responsible for refractoriness of leukemia
and worse outcome of patients. Overexpression of the multidrug resistance gene, MDR1, is …

Although a number of genetic studies have attempted to link the multidrug resistance
(MDR1) C 3435 T polymorphism to risk of leukaemia, the results were often inconsistent …

P-glycoprotein (P-gp), a membrane transporter encoded by MDR1 gene, influences
pharmacokinetics of anti-cancer drugs and contributes to multi-drug resistance phenotype in …

BACKGROUND: The human multidrug-resistant gene (MDR1) encodes P-glycoprotein
(Pgp), a membrane-bound efflux transporter conferring resistance to a number of natural …

One of the limitations in the treatment of cancer patients with chemotherapy is the
development of multidrug resistance (MDR). A well-known mechanism responsible for drug …

The human multidrug resistance gene 1 (MDR1) encodes a plasma membrane, P-
glycoprotein (Pgp), which functions as the transmembrane efflux pump for various …

Background: P-glycoprotein (P-gp), a membrane transporter encoded by the multidrug
resistance-1 (MDR1) gene, influences pharmacokinetics and metabolism of anticancer …