Fiber-optic Raman spectroscopy with nature-inspired genetic algorithms enhances real-time in vivo detection and diagnosis of nasopharyngeal carcinoma

P Zuvela, K Lin, C Shu, W Zheng, CM Lim… - Analytical …, 2019 - ACS Publications
Raman spectroscopy is an optical vibrational spectroscopic technique capable of probing
specific biochemical structures and conformation of tissue and cells in biomedical systems …

Deep Learning-Guided Fiberoptic Raman Spectroscopy Enables Real-Time In Vivo Diagnosis and Assessment of Nasopharyngeal Carcinoma and Post-treatment …

C Shu, H Yan, W Zheng, K Lin, A James… - Analytical …, 2021 - ACS Publications
In this work, we develop a deep learning-guided fiberoptic Raman diagnostic platform to
assess its ability of real-time in vivo nasopharyngeal carcinoma (NPC) diagnosis and post …

[HTML][HTML] Real-time in vivo diagnosis of nasopharyngeal carcinoma using rapid fiber-optic Raman spectroscopy

K Lin, W Zheng, CM Lim, Z Huang - Theranostics, 2017 - ncbi.nlm.nih.gov
We report the utility of a simultaneous fingerprint (FP)(ie, 800-1800 cm-1) and high-
wavenumber (HW)(ie, 2800-3600 cm-1) fiber-optic Raman spectroscopy developed for real …

[HTML][HTML] Real-time in vivo cancer staging of nasopharyngeal carcinoma patients with rapid fiberoptic Raman endoscopy

C Shu, W Zheng, K Lin, CM Lim, Z Huang - Talanta, 2023 - Elsevier
Cancer staging is important to guide treatment and for prognostication. This work aims to
demonstrate the ability of rapid fiberoptic Raman endoscopy for real-time in vivo cancer …

[HTML][HTML] Rapid detection of nasopharyngeal cancer using Raman spectroscopy and multivariate statistical analysis

Y Li, W Huang, J Pan, Q Ye, S Lin… - Molecular and …, 2015 - spandidos-publications.com
Optical spectroscopic techniques, including Raman spectroscopy, have shown promise for
in vivo cancer diagnostics in a variety of organs. In this study, the potential use of a home …

Label-free follow-up surveying of post-treatment efficacy and recurrence in nasopharyngeal carcinoma patients with fiberoptic Raman endoscopy

C Shu, W Zheng, K Lin, C Lim, Z Huang - Analytical Chemistry, 2021 - ACS Publications
Recurrent nasopharyngeal carcinoma (NPC) is the main cause of poor prognosis for NPC
patients after chemo-and radiotherapies. Subsequent long-term follow-ups of post-treatment …

Real-time in vivo diagnosis of laryngeal carcinoma with rapid fiber-optic Raman spectroscopy

K Lin, W Zheng, CM Lim, Z Huang - Biomedical optics express, 2016 - opg.optica.org
We assess the clinical utility of a unique simultaneous fingerprint (FP)(ie, 800-1800 cm^− 1)
and high-wavenumber (HW)(ie, 2800-3600 cm^− 1) fiber-optic Raman spectroscopy for in …

Detection of nasopharyngeal cancer using confocal Raman spectroscopy and genetic algorithm technique

SX Li, QY Chen, YJ Zhang, ZM Liu… - … of biomedical optics, 2012 - spiedigitallibrary.org
Raman spectroscopy (RS) and a genetic algorithm (GA) were applied to distinguish
nasopharyngeal cancer (NPC) from normal nasopharyngeal tissue. A total of 225 Raman …

Optical diagnosis of laryngeal cancer using high wavenumber Raman spectroscopy

K Lin, DLP Cheng, Z Huang - Biosensors and Bioelectronics, 2012 - Elsevier
We report the implementation of the transnasal image-guided high wavenumber (HW)
Raman spectroscopy to differentiate tumor from normal laryngeal tissue at endoscopy. A …

Machine-learning-assisted spontaneous Raman spectroscopy classification and feature extraction for the diagnosis of human laryngeal cancer

Z Li, Z Li, Q Chen, J Zhang, ME Dunham… - Computers in biology …, 2022 - Elsevier
The early detection of laryngeal cancer significantly increases the survival rates, permits
more conservative larynx sparing treatments, and reduces healthcare costs. A non-invasive …