In a microarray study, we found that hepatic miR-291b-3p was significantly increased in
leptin-receptor-deficient type 2 mice (db/db), a mouse model of diabetes. The function of miR …

MicroRNAs are potential therapeutic targets for metabolic diseases. Here, miR-1224-5p was
highly expressed in the livers of mice fed a high-fat diet (HFD) and in obese (ob/ob) mice. To …

AIM: To assess the regulatory effect of microRNA-185 (miR-185) on lipid metabolism and the
insulin signalling pathway in human HepG2 hepatocytes and a high-fat diet mouse model …

MicroRNAs (miRNAs) are endogenous, noncoding, short, single-stranded RNAs that are
evolutionarily conserved and believed to play a role in controlling a variety of biological …

Emerging studies have demonstrated that microRNAs (miRs) are profoundly involved in non-
alcoholic fatty liver disease (NAFLD) and related metabolic diseases. Previously, we …

Background The liver plays a key role in regulating whole body cholesterol homeostasis.
Hepatic cholesterol accumulation causes liver injury in fatty liver disease and …

Although the gluconeogenesis pathway is already a target for the treatment of type 2
diabetes, the potential role of microRNAs (miRNAs) in gluconeogenesis remains unclear …

The expression level of microRNA-802 (miR-802) is increased in livers of high-fat diet (HFD)-
fed mice and obese human subjects; however, the function of miR-802 in the development …

MicroRNAs (miRNAs) are part of a complex regulatory network that modulates cellular lipid
metabolism. Here, we identify miR-124 as a regulator of triglyceride (TG) metabolism. This …

Background: The development of obesity-associated comorbidities such as type 2 diabetes
(T2D) and hepatic steatosis has been linked to selected microRNAs in individual studies; …