Introduction Head-of-bed manipulation is commonly performed in the neurocritical care unit
to optimize cerebral blood flow (CBF), but its effects on CBF are rarely measured. This pilot …

Background This study assesses the utility of a hybrid optical instrument for noninvasive
transcranial monitoring in the neurointensive care unit. The instrument is based on diffuse …

Background Diffuse correlation spectroscopy (DCS) noninvasively permits continuous,
quantitative, bedside measurements of cerebral blood flow (CBF). To test whether optical …

Background Brain tissue oxygen tension (PbtO2) and cerebrovascular pressure reactivity
monitoring have emerged as potential modalities to individualize care in moderate and …

Background and Purpose—A primary goal of acute ischemic stroke (AIS) management is to
maximize perfusion in the affected region and surrounding ischemic penumbra. However …

Background Plateau waves are common in traumatic brain injury. They constitute abrupt
increases of intracranial pressure (ICP) above 40 mmHg associated with a decrease in …

Background Brain tissue partial oxygen pressure (P btO2) and near-infrared spectroscopy
(NIRS) are novel methods to evaluate cerebral oxygenation. We studied the response …

OBJECTIVE Different paradigms for neurocritical care of traumatic brain injury (TBI) have
emerged in conjunction with advanced neuromonitoring technologies and derived metrics …

Object Near-infrared spectroscopy (NIRS) offers noninvasive bedside measurement of direct
regional cerebral arteriovenous (mixed) brain oxygenation. To validate the accuracy of this …

Abstract Background Brain tissue oxygenation (PbtO 2) in traumatic brain injury (TBI) is
known to be dependent on cerebral blood flow (CBF) which remains difficult to assess …