MYC and metabolism on the path to cancer
The MYC proto-oncogene is frequently deregulated in human cancers, activating genetic
programs that orchestrate biological processes to promote growth and proliferation. Altered …
programs that orchestrate biological processes to promote growth and proliferation. Altered …
Regulation of cancer cell metabolism: oncogenic MYC in the driver's seat
Y Dong, R Tu, H Liu, G Qing - Signal transduction and targeted therapy, 2020 - nature.com
Cancer cells must rewire cellular metabolism to satisfy the demands of unbridled growth and
proliferation. As such, most human cancers differ from normal counterpart tissues by a …
proliferation. As such, most human cancers differ from normal counterpart tissues by a …
Molecular pathways: targeting MYC-induced metabolic reprogramming and oncogenic stress in cancer
MYC is a multifunctional transcription factor that is deregulated in many human cancers.
MYC impacts a collaborative genetic program that orchestrates cell proliferation …
MYC impacts a collaborative genetic program that orchestrates cell proliferation …
Therapeutic targeting of Myc-reprogrammed cancer cell metabolism
CV Dang - Cold Spring Harbor symposia on quantitative …, 2011 - symposium.cshlp.org
Studies from many laboratories document that the MYC oncogene produces a pleiotropic
transcription factor, Myc, which influences genes driven by all three RNA polymerases to …
transcription factor, Myc, which influences genes driven by all three RNA polymerases to …
MYC, metabolism, and cancer
The MYC oncogene encodes a transcription factor, MYC, whose broad effects make its
precise oncogenic role enigmatically elusive. The evidence to date suggests that MYC …
precise oncogenic role enigmatically elusive. The evidence to date suggests that MYC …
Metabolic reprogramming by MYCN confers dependence on the serine-glycine-one-carbon biosynthetic pathway
Y Xia, B Ye, J Ding, Y Yu, A Alptekin, M Thangaraju… - Cancer research, 2019 - AACR
MYCN amplification drives the development of neuronal cancers in children and adults.
Given the challenge in therapeutically targeting MYCN directly, we searched for MYCN …
Given the challenge in therapeutically targeting MYCN directly, we searched for MYCN …
MYC, metabolism, cell growth, and tumorigenesis
CV Dang - Cold Spring Harbor perspectives in …, 2013 - perspectivesinmedicine.cshlp.org
The MYC proto-oncogene is frequently activated in human cancers through a variety of
mechanisms. Its deregulated expression, unconstrained by inactivation of key checkpoints …
mechanisms. Its deregulated expression, unconstrained by inactivation of key checkpoints …
[HTML][HTML] Oncogenic regulation of tumor metabolic reprogramming
Abstract Development of malignancy is accompanied by a complete metabolic
reprogramming closely related to the acquisition of most of cancer hallmarks. In fact, key …
reprogramming closely related to the acquisition of most of cancer hallmarks. In fact, key …
Targeting mTOR and metabolism in cancer: lessons and innovations
Cancer cells support their growth and proliferation by reprogramming their metabolism in
order to gain access to nutrients. Despite the heterogeneity in genetic mutations that lead to …
order to gain access to nutrients. Despite the heterogeneity in genetic mutations that lead to …
MYC rules: leading glutamine metabolism toward a distinct cancer cell phenotype
V Tambay, VA Raymond, M Bilodeau - Cancers, 2021 - mdpi.com
Simple Summary In the last decade, metabolic reprogramming has emerged as a driving
characteristic of cancer cells. The MYC oncogene, a transcription factor, has become of …
characteristic of cancer cells. The MYC oncogene, a transcription factor, has become of …