Diverse cellular functions, including tumor suppressor gene expression, DNA repair, cell
proliferation and apoptosis, are regulated by histone acetylation and deacetylation. Histone …

Genetic abnormalities have been conventionally considered as hallmarks of cancer.
However, studies over the past decades have demonstrated that epigenetic regulation also …

The balance of histone acetylation and deacetylation is an epigenetic layer with a critical
role in the regulation of gene expression. Histone acetylation induced by histone acetyl …

Histone deacetylases (HDACs) and histone acetyltransferases are enzymes that regulate
chromatin structure and function through the removal and addition, respectively, of the acetyl …

It has been shown that epigenetic modifications play an important role in tumorigenesis.
Thus, affecting epigenetic tumorigenic alterations can represent a promising strategy for …

Together, histone acetyltransferases and histone deacetylases (HDACs) determine the
acetylation status of histones. This acetylation affects the regulation of gene expression, and …

Histone deacetylases (HDACs) remove the acetyl groups of lysine residues of histone tails
leading to chromatin compaction and transcriptional repression. In addition, HDACs can …

Histone deacetylases (HDACs) play an important role in the epigenetic regulation of gene
expression implicated in cancer pathogenesis. Inhibitors of HDACs (HDI) are under …

Regulation of gene expression is mediated by several mechanisms such as DNA
methylation, ATP-dependent chromatin remodeling, and post-translational modifications of …

The acetylation state of histone is reversibly regulated by histone acetyltransferase (HAT)
and deacetylase (HDAC). An imbalance of this reaction leads to an aberrant behavior of the …