The human genome is epigenetically organized through a series of modifications to the
histone proteins that interact with the DNA. In cancer, many of the proteins that regulate …

Background. Despite recent success toward discovery of more effective anticancer drugs,
chemoresistance remains a major cause of treatment failure. There is emerging evidence …

Histone deacetylases (HDAC) and histone deacetylase inhibitors (HDACi) have greatly
impacted the war on cancer. Their role in epigenetics has significantly altered the …

Epigenetics as well as post-translational modifications of proteins are emerging as novel
attractive targets for anti-cancer therapy. Histone acetyltransferases (HATs) and histone …

Histone acetylation regulates gene transcription. Histone acetylation is a reversible process:
histone acetyltransferases (HAT) transfer the acetyl moiety from acetyl coenzyme A to the …

Epigenetic modifications such as histone modification play an important role in
tumorigenesis. There are several evidence that histone deacetylases (HDACs) play a key …

Acetylation and deacetylation of nucleosomal histones play an important role in the
modulation of chromatin structure, chromatin function and in the regulation of gene …

Esophageal cancer (EC) presents a high mortality rate, mainly due to its aggressive nature.
Squamous cell carcinoma is the most common histological type worldwide, though, a …

Transcriptional regulation in eukaryotes is a multilevel hierarchical process. It is becoming
clear that higher-order chromatin structure, occurring via modifications of histones in their …

Histone deacetylases (HDACs) are involved in chromatin remodeling and modification of
nonhistone transcription regulatory proteins, thus modulating the expression of genes …