Cyclophilin D (CyPD) is thought to sensitize opening of the mitochondrial permeability
transition pore (mPTP) based on the findings that cyclosporin A (CsA), a pseudo-CyPD …

The mitochondrial permeability transition pore (mPTP) plays a critical role in the
pathogenesis of cardiovascular diseases, including ischemia/reperfusion injury. Although …

Cyclophilin D (CyPD) is an important mitochondrial chaperone protein whose mechanism of
action remains a mystery. It is well known for regulating mitochondrial function and coupling …

Cyclophilin D (CypD) is a mitochondrial peptidyl-prolyl cis-trans isomerase, well-known for
regulating the mitochondrial permeability transition pore (PTP), a nonspecific large …

The mitochondrial permeability transition (MPT) plays an important role in damage-induced
cell death, and agents inhibiting the MPT may have a therapeutic potential for treating …

Cyclophilin D (CypD) is a mitochondrial immunophilin and a key positive regulator of the
mitochondrial permeability transition (MPT). Several reports have shown that CypD is …

Cyclophilin-D is a peptidylprolyl cis–trans isomerase of the mitochondrial matrix. It is
involved in mitochondrial permeability transition, in which the adenine nucleotide …

Mitochondria serve as a “powerhouse” which provides near 90% of ATP necessary for cell
life. However, recent studies provide strong evidence that mitochondria also play a central …

Cyclophilin d (cypD)-deficient mice exhibit resistance to focal cerebral ischemia and to
necrotic but not apoptotic stimuli. To address this disparity, we investigated isolated brain …

Cyclophilins are a family of peptidyl-prolyl cis–trans isomerases whose enzymatic activity
can be inhibited by cyclosporin A. Sixteen cyclophilins have been identified in humans, and …