Isolated systolic hypertension (ISH) is a definite risk factor for cardiovascular complications
(ie, cardiac failure, coronary artery disease, and stroke) independent of diastolic elevation …

Objective: Our aim was to compare the effect of lacidipine and chlorthalidone on
cardiovascular outcome as a primary parameter and blood pressure as a secondary in …

Objective To compare with placebo the efficacies of once-daily administrations of lacidipine
and hydrochlorothiazide separately and in combination to elderly patients with systolic …

Background and objective: Isolated systolic hypertension (ISH) affects 10–20% of the elderly
population and is strongly related to the risk of cardiovascular events. Elevated systolic BP …

The pharmacological treatment, mainly based on diuretics, of isolated systolic hypertension
(ISH) has recently been shown to reduce the risk of stroke and coronary heart disease in the …

Pathophysiologic changes and risks associated with isolated systolic hypertension (ISH) are
described, findings of clinical trials pertaining to ISH are summarized, and recommendations …

Background: The benefits of treating isolated systolic hypertension (ISH) are well
established, but the most appropriate drug choice is still uncertain. Objective: The purpose of …

The Systolic Hypertension in Europe (Syst-Eur) study investigated whether antihypertensive
treatment could decrease the risk of cardiovascular complications in elderly patients with …

Abstract The Systolic Hypertension in the Elderly Program (SHEP) is a randomized, blinded
test of the efficacy of antihypertensive drug treatment. In a large feasibility trial, 551 men and …

Evaluating the benefits of an antihypertensive agent using t... : Journal of Hypertension
Evaluating the benefits of an antihypertensive agent using trials based on event and organ …