A comparative evaluation of amlodipine and hydrochlorothiazide as monotherapy in the treatment of isolated systolic hypertension in the elderly

C Calvo, F Gude, J Abellán, J Oliván, M Olmos… - Clinical Drug …, 2000 - Springer
Objective: The purpose of this 8-week, randomised, single-blind, parallel group, multicentre,
comparative study was to evaluate the efficacy, safety and tolerability of the dihydropyridine …

Risk and benefit of treatment of isolated systolic hypertension in the elderly: evidence from the Systolic Hypertension in Europe Trial

H Celis, RH Fagard, JA Staessen… - Current opinion in …, 2001 - journals.lww.com
Abstract The Syst-Eur trial investigated whether active treatment starting with the
dihydropyridine calcium channel blocker (CCB) nitrendipine, could reduce the …

Treatment of arterial hypertension in the elderly with diltiazem vs ramipril.

R Terranova, S Luca - Minerva Cardioangiologica, 2000 - europepmc.org
Background Around 40% of the elderly population suffer from arterial hypertension. An
effective antihypertensive treatment is therefore required. Calcium antagonists are used to …

The potential advantages of a modern antihypertensive therapy in the elderly

F Zannad - Journal of Cardiovascular Pharmacology, 2000 - journals.lww.com
More than 50% of hypertensive patients are aged above 65 years. Physiopathology of
essential hypertension is different in the elderly as compared with the young adult …

Treatment of isolated systolic hypertension in the elderly

D Duprez - Expert review of cardiovascular therapy, 2012 - Taylor & Francis
Systolic hypertension is a major health economy problem within our aging society.
Increased arterial stiffness is the vascular phenotype of systolic hypertension, especially of …

An effective approach for treating elderly patients with isolated systolic hypertension: results of an Italian multicenter study with fosinopril

G Leonetti, B Trimarco, S Collatina… - American journal of …, 1997 - academic.oup.com
Cardiovascular diseases are the most common causes of mortality, and hypertension is the
most common cardiovascular disease in all ages. The Systolic Hypertension in the Elderly …

Treating isolated systolic hypertension in the elderly

PA Howard - Annals of Pharmacotherapy, 1994 - journals.sagepub.com
OBJECTIVE: To review the prevalence, pathophysiology, vascular risk, and treatment of
isolated systolic hypertension (ISH) in the elderly. DATA SOURCE: A MEDLINE search of …

Clinical trials in isolated systolic hypertension

J Gasowski, JG Wang, JA Staessen - Current Hypertension Reports, 1999 - Springer
Isolated systolic hypertension affects 8% to 15% of all people older than 60 years of age. In
the elderly, systolic hypertension is the major modifiable cardiovascular risk factor. Three …

Efficacy and tolerability of lercanidipine in monotherapy in elderly patients with isolated systolic hypertension

M Barbagallo, GB Sangiorgi - Aging Clinical and Experimental Research, 2000 - Springer
To investigate the efficacy and tolerability of lercanidipine, used as monotherapy once a day,
in elderly patients with isolated systolic hypertension (ISH), 83 patients were enrolled in this …

Treatment of isolated systolic hypertension in the elderly: the Syst-Eur trial

RH Fagard, JA Staessen - Clinical and Experimental Hypertension, 1999 - Taylor & Francis
The Syst-Eur study investigated whether active antihypertensive treatment could reduce
cardiovascular complications in elderly patients with isolated systolic hypertension …